Solvent molecules bridge the mechanical unfolding transition state of a protein.
about
Molecular dynamics simulations suggest that electrostatic funnel directs binding of Tamiflu to influenza N1 neuraminidases.Unfolding times for proteins in a force clamp.Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations.Discovery through the computational microscope.Computational and single-molecule force studies of a macro domain protein reveal a key molecular determinant for mechanical stabilityProbing osmolyte participation in the unfolding transition state of a protein.Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy.Thermodynamic analysis of water molecules at the surface of proteins and applications to binding site prediction and characterization.Water's role in the force-induced unfolding of ubiquitin.Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein.Direct quantification of the attempt frequency determining the mechanical unfolding of ubiquitin proteinUsing steered molecular dynamics simulations and single-molecule force spectroscopy to guide the rational design of biomimetic modular polymeric materialsDNA hairpin stabilization on a hydrophobic surface.Osmolyte-induced separation of the mechanical folding phases of ubiquitin.Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry.Single homopolypeptide chains collapse into mechanically rigid conformations.The relationship between water bridges and the polyproline II conformation: a large-scale analysis of molecular dynamics simulations and crystal structures.Understanding biology by stretching proteins: recent progress.Approaches to efficiently estimate solvation and explicit water energetics in ligand binding: the use of WaterMap.Worm-like Ising model for protein mechanical unfolding under the effect of osmolytes.Mechanochemistry: one bond at a time.The effect of temperature on mechanical resistance of the native and intermediate states of I27.An experimentally guided umbrella sampling protocol for biomoleculesHopping around an entropic barrier created by force.Sequence-specific size, structure, and stability of tight protein knots.Pulling-spring modulation as a method for improving the potential-of-mean-force reconstruction in single-molecule manipulation experiments.The structure of glycerol in the liquid state: a neutron diffraction study.Nonexponential kinetics of ion pair dissociation in electrofreezing water.Direct observation of multiple pathways of single-stranded DNA stretching.Transient-state fluctuationlike relation for the driving force on a biomolecule.A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical ReactionsObserving the osmophobic effect in action at the single molecule levelSingle-molecule-level evidence for the osmophobic effectMaximum likelihood estimation of protein kinetic parameters under weak assumptions from unfolding force spectroscopy experimentsStatistics of reversible bond dynamics observed in force-clamp spectroscopyPreferential solvation of lysozyme in water/ethanol mixtures
P2860
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P2860
Solvent molecules bridge the mechanical unfolding transition state of a protein.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@ast
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@en
type
label
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@ast
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@en
prefLabel
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@ast
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@en
P2093
P2860
P356
P1476
Solvent molecules bridge the mechanical unfolding transition state of a protein.
@en
P2093
Julio M Fernandez
P2860
P304
P356
10.1073/PNAS.0706075105
P407
P50
P577
2008-02-27T00:00:00Z