Heme regulates allosteric activation of the Slo1 BK channel
about
The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channelsBK channels: multiple sensors, one activation gateImpact of heme on specific antibody production in mice: promotive, inhibitive or null outcome is determined by its concentration.A BK (Slo1) channel journey from molecule to physiology.Prenatal programming of pulmonary hypertension induced by chronic hypoxia or ductal ligation in sheepCarbon monoxide--physiology, detection and controlled release.Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and COThe RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangementsBK channel activation: structural and functional insightsHeme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channelsPulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway.Designed iron carbonyls as carbon monoxide (CO) releasing molecules: rapid CO release and delivery to myoglobin in aqueous buffer, and vasorelaxation of mouse aortaImpact of heme and heme degradation products on vascular diameter in mouse visual cortexCarbon monoxide as an endogenous vascular modulator.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide.Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels.Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+ (RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP)Initial steps in the opening of a Shaker potassium channel.Multiple facets of maxi-k+ channels: the heme connection.Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain PerceptionIntra- and intersubunit cooperativity in activation of BK channels by Ca2+Mg2+ enhances voltage sensor/gate coupling in BK channels.Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channelsOmega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels.Transduction of voltage and Ca2+ signals by Slo1 BK channels.Molecular mechanisms of BK channel activation.Heme impairs the ball-and-chain inactivation of potassium channelsA point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.Modulation of BKCa channel gating by endogenous signaling molecules.Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography.Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels.Bilirubin oxidation end products directly alter K+ channels important in the regulation of vascular toneComparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels.Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels.Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases.Mg2+-dependent regulation of BK channels: importance of electrostatics.Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling.BK channel inhibition by strong extracellular acidification
P2860
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P2860
Heme regulates allosteric activation of the Slo1 BK channel
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Heme regulates allosteric activation of the Slo1 BK channel
@ast
Heme regulates allosteric activation of the Slo1 BK channel
@en
type
label
Heme regulates allosteric activation of the Slo1 BK channel
@ast
Heme regulates allosteric activation of the Slo1 BK channel
@en
prefLabel
Heme regulates allosteric activation of the Slo1 BK channel
@ast
Heme regulates allosteric activation of the Slo1 BK channel
@en
P2860
P356
P1476
Heme regulates allosteric activation of the Slo1 BK channel
@en
P2093
Frank T Horrigan
Toshinori Hoshi
P2860
P356
10.1085/JGP.200509262
P577
2005-06-13T00:00:00Z