Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
about
Molecular biology of breast tumors and prognosisThe Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsTwo Distinct Types of E3 Ligases Work in Unison to Regulate Substrate UbiquitylationA Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer CompoundsSerotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts.Characterization of Human Cancer Cell Lines by Reverse-phase Protein ArraysImpact of outdated gene annotations on pathway enrichment analysis.g:Profiler-a web server for functional interpretation of gene lists (2016 update)PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer.Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis.Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanismsPlasma exosome microRNAs are indicative of breast cancer.Phospho-BRD4: transcription plasticity and drug targeting.Integrative exploration of genomic profiles for triple negative breast cancer identifies potential drug targets.Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer.Targeting BET bromodomain proteins in solid tumorsCX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumoursImproved anticancer drug response prediction in cell lines using matrix factorization with similarity regularization.Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway.Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells.Defining a Cancer Dependency Map.Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer.Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases.Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.BET Bromodomain Proteins as Cancer Therapeutic Targets.Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer.Prostate-derived Ets factor, an oncogenic driver in breast cancer.Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast CancerCancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.Genotranscriptomic meta-analysis of the CHD family chromatin remodelers in human cancers - initial evidence of an oncogenic role for CHD7.Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.Basal-A Triple Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival.Gene isoforms as expression-based biomarkers predictive of drug response in vitro.A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.The 26S proteasome: A cell cycle regulator regulated by cell cycleTargeted Degradation of BET Proteins in Triple-Negative Breast Cancer.A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.
P2860
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P2860
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@ast
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@en
type
label
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@ast
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@en
prefLabel
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@ast
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@en
P2093
P2860
P50
P1433
P1476
Functional Genomic Landscape o ...... lnerabilities, and Resistance.
@en
P2093
Azin Sayad
Benjamin G Neel
Carl Virtanen
Dana Pe'er
Felix Sanchez-Garcia
Gordon B Mills
James E Bradner
Jason Moffat
Kevin R Brown
Maliha Haider
P2860
P304
P356
10.1016/J.CELL.2015.11.062
P407
P577
2016-01-01T00:00:00Z