Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?The first draft of the endostatin interaction networkSoluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPChaperones in NeurodegenerationIL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidaseStructural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding proteinRole of the subcommissural organ in the pathogenesis of congenital hydrocephalus in the HTx ratDeletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic miceWfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathwayIdentification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's diseaseIs Transthyretin a Regulator of Ubc9 SUMOylation?Transthyretin variants with improved inhibition of β-amyloid aggregation.Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid.Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Transthyretin-derived peptides as β-amyloid inhibitors.Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndromeAssociation of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers.Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Serum and cerebrospinal fluid levels of transthyretin in Lewy body disorders with and without dementia.The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice.Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model.N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice.Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD studyMechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs.Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin.Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures.Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neuronsLongitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome.Cystatin C in Alzheimer's disease.Up-Regulation of Antioxidant Proteins in the Plasma Proteome during Saturation Diving: Unique Coincidence under Hypobaric Hypoxia.Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry.17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain
P2860
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P2860
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@ast
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@en
type
label
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@ast
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@en
prefLabel
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@ast
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@en
P2093
P2860
P50
P356
P1476
Transthyretin protects Alzheim ...... cal effects of Abeta toxicity.
@en
P2093
Amanda R Roberts
Coree Levy
Linsey Friske
Natàlia Reixach
Pritam Das
Todd Golde
Zhengyi Ye
P2860
P304
P356
10.1073/PNAS.0712197105
P407
P577
2008-02-12T00:00:00Z