about
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylaseHDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulationEnzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promotersSide chain specificity of ADP-ribosylation by a sirtuinThe NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian controlSIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activatorSIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysineSRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcriptionThe neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodiesFOXO3A genotype is strongly associated with human longevityDisruption of the Ang II type 1 receptor promotes longevity in miceSIRT6 in DNA repair, metabolism and ageingAcylation of Biomolecules in Prokaryotes: a Widespread Strategy for the Control of Biological Function and Metabolic StressProtective effects and mechanisms of sirtuins in the nervous systemTargeting sirtuin 1 to improve metabolism: all you need is NAD(+)?NAD+ as a signaling molecule modulating metabolismLysine deacetylase (KDAC) regulatory pathways: an alternative approach to selective modulationRedox regulation of SIRT1 in inflammation and cellular senescenceSirtuins in epigenetic regulationProtein lysine acylation and cysteine succination by intermediates of energy metabolismStructural Insights into Intermediate Steps in the Sir2 Deacetylation ReactionStructure and reaction mechanism of human nicotinamide phosphoribosyltransferaseHigh-Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into the Catalytic Mechanism and Inhibition by Aldehydes,The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl LysineA Molecular Mechanism for Direct Sirtuin Activation by ResveratrolStructural basis for allosteric stimulation of Sir2 activity by Sir4 bindingEx-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismStructural and Functional Analysis of Human SIRT1Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanismStructural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferaseMitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modificationsChemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitorsHst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.Epigenetics and Cellular MetabolismThe promise and perils of HDAC inhibitors in neurodegenerationPhenotypic plasticity in fungi: a review with observations on Aureobasidium pullulansEvidence for a common mechanism of SIRT1 regulation by allosteric activatorsSirt1 activation by resveratrol is substrate sequence-selective
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
The biochemistry of sirtuins.
@ast
The biochemistry of sirtuins.
@en
type
label
The biochemistry of sirtuins.
@ast
The biochemistry of sirtuins.
@en
prefLabel
The biochemistry of sirtuins.
@ast
The biochemistry of sirtuins.
@en
P1476
The biochemistry of sirtuins
@en
P2093
Anthony A Sauve
Vern L Schramm
P304
P356
10.1146/ANNUREV.BIOCHEM.74.082803.133500
P577
2006-01-01T00:00:00Z