Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. - Wikidata - awgldk - TriplyDB

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

http://www.wikidata.org/entity/Q36502902

about

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1 A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*Ubiquitin in the activation and attenuation of innate antiviral immunity The role of ubiquitylation in immune defence and pathogen evasion Host innate immune responses to sepsis Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937 Ubiquitin in the immune system Innate immune signaling in defense against intestinal microbes Linear ubiquitination in immunity Does antigen masking by ubiquitin chains protect from the development of autoimmune diseases?A20 deficiency causes spontaneous neuroinflammation in mice The Trypanosoma cruzi protease cruzain mediates immune evasion Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system Inflammatory bowel disease Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase RNF11, a new piece in the A20 puzzle.Hypomorphic A20 expression confers susceptibility to psoriasis.Oncogenic activation of NF-kappaB.CD47 and TLR-2 cross-talk regulates neutrophil transmigration.The regulation of TGF-β/SMAD signaling by protein deubiquitination.Molecular control of steady-state dendritic cell maturation and immune homeostasis.Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.Toll-like receptors in kidney disease.Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions.The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.MTA1 coregulator regulates LPS response via MyD88-dependent signaling Toll-like receptors in inflammatory bowel diseases: a decade later.Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice.Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.Ubiquitin makes its mark on immune regulation.A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination.Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.

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P2860

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

http://www.wikidata.org/entity/Q36502902

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

@ast

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

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type

label

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

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Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

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prefLabel

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

@ast

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

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Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

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Averil Ma

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Barbara A Malynn

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Bettina Lee

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Nataliya Shifrin

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Osamu Hitotsumatsu

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Rommel Advincula

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P2860

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

IRAK-M is a negative regulator of Toll-like receptor signaling

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

TLR signaling pathways

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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451-464

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10.1084/JEM.20071108

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18268035

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2271029

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