The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
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Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3Remodelling the extracellular matrix in development and diseaseStructural basis for the sheddase function of human meprin metalloproteinase at the plasma membraneProteomic Substrate Identification for Membrane Proteases in the BrainBiochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decadeEvaluation of ¹¹¹in-labelled exendin-4 derivatives containing different meprin β-specific cleavable linkersN-Terminal-oriented proteogenomics of the marine bacterium roseobacter denitrificans Och114 using N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP) labeling and diagonal chromatography.ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.Urinary signatures of Renal Cell Carcinoma investigated by peptidomic approaches.In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates.Origin and Diversification of Meprin Proteases.Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migrationThe metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.Meprin A metalloproteinase and its role in acute kidney injury.The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strengthTime-resolved analysis of the matrix metalloproteinase 10 substrate degradome.Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.Matrix metalloproteinase processing of signaling molecules to regulate inflammation.Proteomic identification of protease cleavage sites: cell-biological and biomedical applications.Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets.Proteases and proteomics: cutting to the core of human skin pathologies.Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases.Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity.Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.
P2860
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P2860
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The substrate degradome of mep ...... k between meprin β and ADAM10.
@ast
The substrate degradome of mep ...... k between meprin β and ADAM10.
@en
type
label
The substrate degradome of mep ...... k between meprin β and ADAM10.
@ast
The substrate degradome of mep ...... k between meprin β and ADAM10.
@en
prefLabel
The substrate degradome of mep ...... k between meprin β and ADAM10.
@ast
The substrate degradome of mep ...... k between meprin β and ADAM10.
@en
P2093
P2860
P50
P1476
The substrate degradome of mep ...... k between meprin β and ADAM10.
@en
P2093
Anke Ohler
Arumugam Jayakumar
Athena Chalaris
Caroline Bellac
Christoph Becker-Pauly
Claudia Broder
Claus U Pietrzik
Erwin Sterchi
Heiko Traupe
Jana Hedrich
P2860
P2888
P304
P356
10.1007/S00018-012-1106-2
P577
2012-09-01T00:00:00Z