Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors - Wikidata - awgldk - TriplyDB

Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors

Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors

http://www.wikidata.org/entity/Q36509182

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Synthesis and Evaluation of Tricarbonyl (99m)Tc-Labeled 2-(4-Chloro)phenyl-imidazo[1,2-a]pyridine Analogs as Novel SPECT Imaging Radiotracer for TSPO-Rich Cancer Imaging of atherosclerosis Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker Inflammation imaging in atherosclerosis Towards molecular imaging of multiple sclerosis.Cyclooxygenase and neuroinflammation in Parkinson's disease neurodegeneration.In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28.Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.Biodistribution and radiation dosimetry in humans of a new PET ligand, (18)F-PBR06, to image translocator protein (18 kDa).Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.Comparison of 18F- and 11C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography Mixed-affinity binding in humans with 18-kDa translocator protein ligands.Evaluation of [(11)C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis.Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation.Microglial activation and progressive brain changes in schizophrenia.A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders.Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.Fully automated synthesis and initial PET evaluation of [11C]PBR28 Stroke incidentally identified using improved positron emission tomography for microglial activation Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06.Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity.Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates.PET Imaging in Huntington's Disease.Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [11 C]PBR28.Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.The translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo.In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis.Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects.Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein.[11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat.Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap-luc mice.PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia.Improved Automated Radiosynthesis of [(11)C]PBR28.The development of an automated and GMP compliant FASTlab™ Synthesis of [(18) F]GE-180; a radiotracer for imaging translocator protein (TSPO).Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases.

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Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors

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Jinsoo Hong

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Jonathan P Gourley

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Masahiro Fujita

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Masao Imaizumi

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Robert B Innis

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Sami S Zoghbi

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Victor W Pike

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Yota Fujimura

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Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Visualising microglial activation in vivo.

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106.

Consensus nomenclature for in vivo imaging of reversibly binding radioligands.

Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain.

The peripheral benzodiazepine receptor: a promising therapeutic drug target.

High densities of benzodiazepine receptors in human cortical areas.

PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.

[(11)C]DAA1106: radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain.

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