Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. - Wikidata - awgldk - TriplyDB

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.

http://www.wikidata.org/entity/Q36509892

about

Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression Immunologic changes in frail older adults The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude Mechanisms shaping the naïve T cell repertoire in the elderly - thymic involution or peripheral homeostatic proliferation?T cell replicative senescence in human aging Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function Dynamics of the CD8 T-cell response following yellow fever virus 17D immunization Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection.Prospects for developing an effective particle-mediated DNA vaccine against influenza.Role of CD8(+) T-cell immunity in influenza infection: potential use in future vaccine development.Study on age-dependent pre-existing 2009 pandemic influenza virus T and B cell responses from Chinese population Antibody correlates and predictors of immunity to naturally occurring influenza in humans and the importance of antibody to the neuraminidase.Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool.VDJviz: a versatile browser for immunogenomics data.Thymic fatness and approaches to enhance thymopoietic fitness in aging.Effects of aging on the adaptive immune response to respiratory virus infections.Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.Leukocyte function in the aging immune system.Quantification of HTLV-1 clonality and TCR diversity.Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion Functional CD8 T cell memory responding to persistent latent infection is maintained for life.Targeting inhibitory pathways in cancer immunotherapy.Maintenance of immune tolerance to a neo-self acetylcholine receptor antigen with aging: implications for late-onset autoimmunity Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire.Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution.Immune memory and aging: an infinite or finite resource?Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection.Enhancement of virus-specific expansion of transgenic CD8 T cells in aged mice by dendritic cells.The narrowing of the CD8 T cell repertoire in old age Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice.Impact of aging on viral infections.Immune senescence: relative contributions of age and cytomegalovirus infection Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity Evaluation of the tuberculosis programme in Ningxia Hui Autonomous region, the People's Republic of China: a retrospective case study.Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells.Diversity and clonal selection in the human T-cell repertoire.

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P2860

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.

http://www.wikidata.org/entity/Q36509892

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Age-associated decline in T ce ...... d immunity to influenza virus.

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Age-associated decline in T ce ...... d immunity to influenza virus.

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type

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Age-associated decline in T ce ...... d immunity to influenza virus.

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Age-associated decline in T ce ...... d immunity to influenza virus.

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Age-associated decline in T ce ...... d immunity to influenza virus.

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Journal of Experimental Medicine

P1476

Age-associated decline in T ce ...... d immunity to influenza virus.

@en

P2093

David L Woodland

http://www.w3.org/2001/XMLSchema#string

Kathleen Lanzer

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Marcia A Blackman

http://www.w3.org/2001/XMLSchema#string

Mushtaq Ahmed

http://www.w3.org/2001/XMLSchema#string

Troy D Randall

http://www.w3.org/2001/XMLSchema#string

P2860

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

The influence of age on T cell generation and TCR diversity

Phenotypic analysis of antigen-specific T lymphocytes

A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge.

Is immune senescence reversible?

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses

Requirement for CD4 T cell help in generating functional CD8 T cell memory.

Age-related changes in lymphocyte development and function.

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.

The aging of the immune system.

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711-723

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10.1084/JEM.20071140

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3

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205

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2008-03-10T00:00:00Z

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18332179

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2275391

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