Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice.
about
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activationSignaling by the kinase MINK is essential in the negative selection of autoreactive thymocytesTranscriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptorLineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapieT cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunityConcurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo.Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate.Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.Thymus epithelium induces tissue-specific toleranceThe T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells.Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cellsDuring negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestineImmature thymocytes are protected from deletion early in ontogeny.Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.Involvement of p21ras distinguishes positive and negative selection in thymocytes.Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.Characterization of two TCR transgenic mouse lines specific for herpes simplex virus.Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells.Different Role of Apaf-1 in Positive Selection, Negative Selection and Death by Neglect in Foetal Thymic Organ Culture
P2860
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P2860
Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Early deletion and late positi ...... cell receptor transgenic mice.
@ast
Early deletion and late positi ...... cell receptor transgenic mice.
@en
type
label
Early deletion and late positi ...... cell receptor transgenic mice.
@ast
Early deletion and late positi ...... cell receptor transgenic mice.
@en
prefLabel
Early deletion and late positi ...... cell receptor transgenic mice.
@ast
Early deletion and late positi ...... cell receptor transgenic mice.
@en
P2093
P356
P1433
P1476
Early deletion and late positi ...... cell receptor transgenic mice.
@en
P2093
P356
10.1155/1990/18208
P577
1990-01-01T00:00:00Z