Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. - Wikidata - awgldk - TriplyDB

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

http://www.wikidata.org/entity/Q36511945

about

DNA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance Radioresistance of Brain Tumors Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway The impact of the myeloid response to radiation therapy Cancer stem cells and radioresistance Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells TGF-β signaling and its targeting for glioma treatment Interstitial flow differentially increases patient-derived glioblastoma stem cell invasion via CXCR4, CXCL12, and CD44-mediated mechanisms.The roles of TGFβ in the tumour microenvironment.The evolving landscape of glioblastoma stem cells.Host mediated inflammatory influence on glioblastoma multiforme recurrence following high-dose ionizing radiation.A proposed quantitative index for assessing the potential contribution of reprogramming to cancer stem cell kinetics.Breast cancer stem cells: Multiple capacities in tumor metastasis.Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis Proton irradiation augments the suppression of tumor progression observed with advanced age.LY2109761 enhances cisplatin antitumor activity in ovarian cancer cells.TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization.Ionizing radiation in glioblastoma initiating cells.Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation.Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche.Prioritization schema for immunotherapy clinical trials in glioblastoma.Immune-checkpoint blockade and active immunotherapy for glioma.Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor.Redox-mediated and ionizing-radiation-induced inflammatory mediators in prostate cancer development and treatment.Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer.Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas.Interleukins in glioblastoma pathophysiology: implications for therapy.Current progress for the use of miRNAs in glioblastoma treatment.Transforming growth factor-beta and its implication in the malignancy of gliomas.Glioblastoma stem cells: Molecular characteristics and therapeutic implications Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation.Stem cells and gliomas: past, present, and future.New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability.Molecular targets in glioblastoma.

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P2860

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

http://www.wikidata.org/entity/Q36511945

description

2012 nî lūn-bûn

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Resistance of glioblastoma-ini ...... transforming growth factor-β.

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Resistance of glioblastoma-ini ...... transforming growth factor-β.

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Resistance of glioblastoma-ini ...... transforming growth factor-β.

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Resistance of glioblastoma-ini ...... transforming growth factor-β.

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Resistance of glioblastoma-ini ...... transforming growth factor-β.

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Resistance of glioblastoma-ini ...... transforming growth factor-β.

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0008-5472.CAN-12-0546

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Cancer Research

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Resistance of glioblastoma-ini ...... g transforming growth factor-β

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Ashwatha Narayana

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Christina M Medina-Ramirez

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David Zagzag

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Mary Helen Barcellos-Hoff

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Matthew E Hardee

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Scott M Lonning

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P2860

Cancerous stem cells can arise from pediatric brain tumors

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Identification of a cancer stem cell in human brain tumors

Redox-mediated activation of latent transforming growth factor-beta 1

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains.

Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.

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4119-4129

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22693253

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3538149

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