Imaging a functional tumorigenic biomarker in the transformed epithelium
about
Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane ProteinsHuman cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activationNon-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesisCombinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1Imaging active urokinase plasminogen activator in prostate cancer.Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration.Type II transmembrane serine proteases as potential targets for cancer therapy.Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistanceDeregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.In vivo imaging of protease activity by Probody therapeutic activation.Cancer associated proteins in blood plasma: Determining normal variation.The role of type II transmembrane serine protease-mediated signaling in cancer.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index.Probody therapeutics for targeting antibodies to diseased tissue.
P2860
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P2860
Imaging a functional tumorigenic biomarker in the transformed epithelium
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Imaging a functional tumorigenic biomarker in the transformed epithelium
@ast
Imaging a functional tumorigenic biomarker in the transformed epithelium
@en
type
label
Imaging a functional tumorigenic biomarker in the transformed epithelium
@ast
Imaging a functional tumorigenic biomarker in the transformed epithelium
@en
prefLabel
Imaging a functional tumorigenic biomarker in the transformed epithelium
@ast
Imaging a functional tumorigenic biomarker in the transformed epithelium
@en
P2093
P2860
P356
P1476
Imaging a functional tumorigenic biomarker in the transformed epithelium
@en
P2093
Aaron M LeBeau
Byron C Hann
Charles S Craik
Henry F VanBrocklin
John Kurhanewicz
Minhee Lee
Robert S Warren
Romelyn Delos Santos
Samir M Hanash
Stephanie T Murphy
P2860
P356
10.1073/PNAS.1218694110
P407
P577
2012-12-17T00:00:00Z