Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
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Personalized Medicine for Nervous System Manifestations of von Hippel-Lindau DiseaseSequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspectiveHypoxic control of metastasisTargeting Breast Cancer MetastasisRole of DNA methylation in renal cell carcinomaHarnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesisHistone deacetylase inhibitors and epigenetic modifications as a novel strategy in renal cell carcinomaOn-target efficacy of a HIF-2α antagonist in preclinical kidney cancer modelsMetastatic colonization by circulating tumour cellsEpigenetic determinants of metastasisCancer Cells Hijack PRC2 to Modify Multiple Cytokine PathwaysNfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility.High CXC chemokine receptor 4 expression is an adverse prognostic factor in patients with clear-cell renal cell carcinomaDNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia.Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approachesPossible prognostic and therapeutic significance of c-Kit expression, mast cell count and microvessel density in renal cell carcinoma.Reduced ING1 levels in breast cancer promotes metastasisDirect regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma.Subtyping of renal cortical neoplasms in fine needle aspiration biopsies using a decision tree based on genomic alterations detected by fluorescence in situ hybridizationGenomic insights into cancer-associated aberrant CpG island hypermethylationThe multifaceted von Hippel-Lindau tumour suppressor protein.The intricate role of CXCR4 in cancer.Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma.DNA methylation biomarkers predict progression-free and overall survival of metastatic renal cell cancer (mRCC) treated with antiangiogenic therapies.Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model.ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer.Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New MutationsTumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and MetastasisEnhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis.Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesisIntegrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination.HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenesRole of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features.Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.Redox imbalance and biochemical changes in cancer.Complex role of HIF in cancer: the known, the unknown, and the unexpected.Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells.
P2860
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P2860
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Epigenetic expansion of VHL-HI ...... an metastasis in renal cancer.
@ast
Epigenetic expansion of VHL-HI ...... an metastasis in renal cancer.
@en
type
label
Epigenetic expansion of VHL-HI ...... an metastasis in renal cancer.
@ast
Epigenetic expansion of VHL-HI ...... an metastasis in renal cancer.
@en
prefLabel
Epigenetic expansion of VHL-HI ...... an metastasis in renal cancer.
@ast
Epigenetic expansion of VHL-HI ...... an metastasis in renal cancer.
@en
P2093
P2860
P356
P1433
P1476
Epigenetic expansion of VHL-HI ...... gan metastasis in renal cancer
@en
P2093
A Ari Hakimi
Adriana Heguy
Agnes Viale
Fabienne Brenet
James J-D Hsieh
Sakari Vanharanta
Victor E Reuter
Weiping Shu
P2860
P2888
P356
10.1038/NM.3029
P407
P577
2012-12-09T00:00:00Z