Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
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The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPPRecent advances in the molecular genetics of type 2 diabetes mellitusA flash in the pan: dissecting dynamic amyloid intermediates using fluorescenceInhibition of IAPP Aggregation and Toxicity by Natural Products and DerivativesExecution of RIPK3-regulated necrosisOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesEffects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure.α-helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes.Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: innocent bystanders or partners in a crime?Amyloid aggregation and deposition of human islet amyloid polypeptide at membrane interfaces.Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid BilayersAmylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's diseasePancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species.Protein folding and aggregation into amyloid: the interference by natural phenolic compoundsLipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78)Mutations and seeding of amylin fibril-like oligomers.Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.Beneficial properties of natural phenols: highlight on protection against pathological conditions associated with amyloid aggregation.Ion channels in regulated cell death.Structural studies and cytotoxicity assays of "aggregation-prone" IAPP(8-16) and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation.The role of copper(II) in the aggregation of human amylin.Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design.The Role of Cholesterol in Driving IAPP-Membrane Interactions.Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.Tubulation of liposomes via the interaction of supramolecular nanofibers.Islet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition.Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition.Fluorescent dye ProteoStat to detect and discriminate intracellular amyloid-like aggregates in Escherichia coli.Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo.Impact of membrane curvature on amyloid aggregation.
P2860
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P2860
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
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2013年論文
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name
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
@ast
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
@en
type
label
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
@ast
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
@en
prefLabel
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
@ast
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.
@en
P2860
P50
P1433
P1476
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP
@en
P2093
Grazia M L Messina
P2860
P304
P356
10.1016/J.BPJ.2012.11.3811
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P50
P577
2013-01-08T00:00:00Z