Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region
about
Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domainsLMBD1 protein serves as a specific adaptor for insulin receptor internalizationAntibody binding to the juxtamembrane region of the insulin receptor alters receptor affinity.Cell surface receptors for signal transduction and ligand transport: a design principles study.Early steps in insulin action.Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathwaysSpecific factors are required for kinase-dependent endocytosis of insulin receptors.Receptor downregulation and desensitization enhance the information processing ability of signalling receptors.Computational modelling of bovine ovarian follicle development.Two steps of insulin receptor internalization depend on different domains of the beta-subunit.Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsOptimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobilityThe insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.Insulin receptor kinase activation releases a constraint maintaining the receptor on microvilli.Endocytosis of receptor tyrosine kinasesAssociation of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1.Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking.C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity.Regulation of targeting signals in membrane proteins. [review]Structure and function of the insulin-like growth factor I receptor.Chloroquine augments the binding of insulin to its receptor.Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification.Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor.Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.Extracellular matrix proteins modulate endocytosis of the insulin receptor.Correlated receptor transport processes buffer single-cell heterogeneity.Annexin II is a novel player in insulin signal transduction. Possible association between annexin II phosphorylation and insulin receptor internalization.
P2860
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P2860
Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Insulin receptors internalize ...... an intact juxtamembrane region
@ast
Insulin receptors internalize ...... an intact juxtamembrane region
@en
type
label
Insulin receptors internalize ...... an intact juxtamembrane region
@ast
Insulin receptors internalize ...... an intact juxtamembrane region
@en
prefLabel
Insulin receptors internalize ...... an intact juxtamembrane region
@ast
Insulin receptors internalize ...... an intact juxtamembrane region
@en
P2093
P2860
P356
P1476
Insulin receptors internalize ...... an intact juxtamembrane region
@en
P2093
J M Backer
S E Shoelson
P2860
P304
P356
10.1083/JCB.115.6.1535
P407
P577
1991-12-01T00:00:00Z