Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. - Wikidata - awgldk - TriplyDB

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.

http://www.wikidata.org/entity/Q36534628

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Ubiquitin-proteasome system involvement in Huntington's disease Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models The ubiquitin proteasome system in neuropathology Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease.Aging is not associated with proteasome impairment in UPS reporter mice.The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain.Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes.Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation.BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis.Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease.Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems.Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases.Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.Transglutaminase activation in neurodegenerative diseases.Transglutaminases and neurodegeneration.Impaired mitochondrial trafficking in Huntington's disease.Nuclear accumulation of polyglutamine disease proteins and neuropathology.scyllo-Inositol promotes robust mutant Huntingtin protein degradation.Basic mechanisms of neurodegeneration: a critical update.

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P2860

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.

http://www.wikidata.org/entity/Q36534628

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

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Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

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Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

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Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

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Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

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Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

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Journal of Cell Biology

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Impaired ubiquitin-proteasome ...... of Huntington's disease mice.

@en

P2093

Adam Orr

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Chuan-En Wang

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Jianjun Wang

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Shi-Hua Li

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Suzanne Tydlacka

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Xiao-Jiang Li

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P2860

The ubiquitin system

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

Trinucleotide Repeat Disorders

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1177-1189

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scholarly article

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10.1083/JCB.200709080

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6

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180

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2008-03-01T00:00:00Z

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5490546

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18362179

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P921

Huntington disease

ubiquitin-proteasome system

P932

2290845

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