Design principles of a universal protein degradation machine.
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Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugatesStabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo SpecificityE2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitinStructure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradationCuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response.Fundamental Characteristics of AAA+ Protein Family Structure and FunctionBacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasomeRegulated protein turnover: snapshots of the proteasome in action.Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs).Therapeutic landscape of carfilzomib and other modulators of the ubiquitin-proteasome pathway.Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome AssemblyOpen-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradationLigand-induced and small-molecule control of substrate loading in a hexameric helicaseMarching to the beat of the ring: polypeptide translocation by AAA+ proteases.Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis.Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines.Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates.AAA-ATPases in Protein Degradation.The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.Regulating protein breakdown through proteasome phosphorylation.The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.Induction of proteotoxic stress by the mycotoxin patulin.POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim.
P2860
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P2860
Design principles of a universal protein degradation machine.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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2012年论文
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2012年论文
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name
Design principles of a universal protein degradation machine.
@ast
Design principles of a universal protein degradation machine.
@en
type
label
Design principles of a universal protein degradation machine.
@ast
Design principles of a universal protein degradation machine.
@en
prefLabel
Design principles of a universal protein degradation machine.
@ast
Design principles of a universal protein degradation machine.
@en
P2860
P1476
Design principles of a universal protein degradation machine.
@en
P2093
Andreas Martin
Mary E Matyskiela
P2860
P304
P356
10.1016/J.JMB.2012.11.001
P407
P577
2012-11-09T00:00:00Z