about
Data-driven identification of structural alerts for mitigating the risk of drug-induced human liver injuriesImpact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, GabonAssessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric AssayProposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes.New insights into the intracellular distribution pattern of cationic amphiphilic drugs.Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screeningMitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance.Application of a homogenous membrane potential assay to assess mitochondrial function.The anti-mitochondrial antifungal assay for the discovery and development of new drugs.High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I.The acute extracellular flux (XF) assay to assess compound effects on mitochondrial function.Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome ActivationA flavone-polysaccharide based prescription attenuates the mitochondrial dysfunction induced by duck hepatitis A virus type 1Yeast sensors for novel drugs: chloroquine and others revealedStrategies to reduce late-stage drug attrition due to mitochondrial toxicity.Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity.Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.Mechanisms of cell death in acute liver failure.An overview of transcriptional regulation in response to toxicological insult.Evaluation of drug-induced injury and human response in precision-cut tissue slices.Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action.Drug safety testing paradigm, current progress and future challenges: an overview.Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition.Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats.A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells.Predicting in vivo safety characteristics using physiochemical properties and in vitro assays.Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon.Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes.Liver Effects of Clinical Drugs Differentiated in Human Liver Slices.Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.The effect of antiepileptic drugs on mitochondrial activity: a pilot study.Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors.Sulfasalazine induces mitochondrial dysfunction and renal injury.Wheat germ supplementation alleviates insulin resistance and cardiac mitochondrial dysfunction in an animal model of diet-induced obesity.The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.In vitro/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine.Toxicity of lithium on isolated heart mitochondria and cardiomyocyte: A justification for its cardiotoxic adverse effect.Mitochondrial Toxicity.
P2860
Q27902347-18DBDE56-3DC9-4A4E-B362-74EC756503BBQ28547359-53DD472A-ED4E-4787-8D91-6375760434B9Q28831460-A76791D8-6A78-4055-BA6E-CF5CEFF475CFQ30828343-0082BEF3-2A2F-4FE6-A1DE-B6D32DFCF0FCQ30841407-76CE8CAE-327B-4633-BCC1-BC98D33EE78BQ33269368-03544E3B-AFAF-4AFA-A60A-C5C7C5508C77Q33668501-0A05F8C2-73F4-455F-991C-55D8D230E143Q34015408-D6B00982-EFFD-42EB-9909-910EBE48E737Q34203882-2BD321B5-3226-4D89-B57D-792CFA344AF4Q34278041-317AA9E6-D2E1-4BC7-B033-E1D761F46718Q34786843-87E7239A-6CA0-470A-9C70-35EAD525C155Q35045143-3D78D915-6C08-4313-9F49-D428054E6D5BQ35405000-6582BDC4-8A96-4230-8133-42503E138B95Q36283837-5D299AA6-B0D8-4EB3-B82A-635EB49AAB22Q36342255-3BA0949E-1F4B-47D1-87DA-209B0FA09540Q36534476-5D02A4DA-B15A-4799-B6FF-C3891FEE3C63Q36748508-FE36B056-B3E5-458E-9FB1-59BAF8575F6CQ37541019-49D82502-3A89-497E-A5B9-DE422F6DC190Q37599014-6AD49E68-8721-4C5B-9FC9-EBE187E595E7Q38000987-72903B2D-EC81-4795-BA8F-CE151648B996Q38038498-823E2548-0BDB-4760-93A3-30CC60840B9FQ38055199-227335A7-D965-4128-ABD9-B81691DCBD04Q38123214-ADFAC781-C176-443E-85E2-0175B8AB2546Q38207946-502C73CB-4B15-4BE0-A27F-F88E2840AA5DQ38704329-D3D8034D-114F-48FA-BB90-34CB0BEB4227Q38883310-66FE984A-BD9E-425A-ABB6-D02B46067D21Q38962365-3D40DD9E-373F-4E10-870E-53D9895D06ACQ39481089-9381C0AA-B319-4A45-B5E0-F5893CEC821CQ40482916-2A54E3B7-4188-4DD5-B106-42E747D97742Q41626712-BE0FCA26-3D28-4B5D-BEBE-A7B8D1724F9EQ41951728-B4B39EEF-C035-419C-9871-6687C448338BQ42700015-71E8472B-0BFD-44DD-A848-28AFF7987110Q43088233-1C259CE1-0B47-4F4C-B44D-2A3B692B5D52Q44255490-394B4EC6-117E-4D21-8F9E-FDB2C398D11FQ46246206-0141154B-F112-431F-A7D6-D92D82EE96E0Q46311501-576ED941-6D95-4109-BB8A-6960EF752310Q46428440-E7D17C7A-DB31-459C-B215-357D79CAEF78Q46465683-06088AB5-CB8A-458E-8D2E-F8F5CAC94B63Q46494229-0B3A2243-EB8A-40E6-89FD-245AF0CD6F5DQ47728491-2B42B05D-E5FF-4714-AB48-19F10526E313
P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Drug-induced mitochondrial toxicity.
@ast
Drug-induced mitochondrial toxicity.
@en
type
label
Drug-induced mitochondrial toxicity.
@ast
Drug-induced mitochondrial toxicity.
@en
prefLabel
Drug-induced mitochondrial toxicity.
@ast
Drug-induced mitochondrial toxicity.
@en
P2093
P2860
P356
P1476
Drug-induced mitochondrial toxicity.
@en
P2093
Don Truong
Katie Chan
Nandita Shangari
Peter J O'Brien
P2860
P304
P356
10.1517/17425255.1.4.655
P407
P577
2005-12-01T00:00:00Z