Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases
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Deciphering the structural basis of eukaryotic protein kinase regulationCo-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailHydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional SpecializationLocking the active conformation of c-Src kinase through the phosphorylation of the activation loopStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factorsFunctional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases.Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralogKinView: a visual comparative sequence analysis tool for integrated kinome research.ProKinO: a unified resource for mining the cancer kinome.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of Ephrin tyrosine kinase evolution.
P2860
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P2860
Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Identification of a hidden str ...... l mechanism in protein kinases
@ast
Identification of a hidden str ...... l mechanism in protein kinases
@en
type
label
Identification of a hidden str ...... l mechanism in protein kinases
@ast
Identification of a hidden str ...... l mechanism in protein kinases
@en
prefLabel
Identification of a hidden str ...... l mechanism in protein kinases
@ast
Identification of a hidden str ...... l mechanism in protein kinases
@en
P2093
P2860
P356
P1476
Identification of a hidden str ...... l mechanism in protein kinases
@en
P2093
Krishnadev Oruganty
Nakul Suhas Talathi
Natarajan Kannan
Zachary A Wood
P2860
P304
P356
10.1073/PNAS.1207104110
P407
P577
2012-12-31T00:00:00Z