Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.

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Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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name

Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

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Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

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label

Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

@ast

Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

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Targeting ERK1/2-bim signaling ...... eutic strategy for oral cancer

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Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

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Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

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P1476

Targeting ERK1/2-bim signaling ...... utic strategy for oral cancer.

@en

P2093

Hae Nim Lee

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In-Sun Hong

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Ji-Ae Shin

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Ji-Youn Jung

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Joseph H Jeong

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Lee-Han Kim

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Sook-Jeong Lee

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Sung-Dae Cho

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P2860

Hallmarks of Cancer: The Next Generation

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

Movement of Bax from the cytosol to mitochondria during apoptosis

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

P304

35667-35683

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P31

scholarly article

P356

10.18632/ONCOTARGET.5523

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P407

English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2015-10-02T00:00:00Z

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P698

26447615

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P921

ABT-737

Bcl-2 family

Oral Cancer

P932

4742133

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