Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
about
Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models.Targeting the ATR-CHK1 Axis in Cancer TherapyAlternative Chk1-independent S/M checkpoint in somatic cells that prevents premature mitotic entry.Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity.Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.ATR/CHK1 inhibitors and cancer therapy.A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells.Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells.
P2860
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P2860
Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Identification of novel, in vi ...... structure guided drug design.
@ast
Identification of novel, in vi ...... structure guided drug design.
@en
type
label
Identification of novel, in vi ...... structure guided drug design.
@ast
Identification of novel, in vi ...... structure guided drug design.
@en
prefLabel
Identification of novel, in vi ...... structure guided drug design.
@ast
Identification of novel, in vi ...... structure guided drug design.
@en
P2093
P2860
P356
P1433
P1476
Identification of novel, in vi ...... structure guided drug design.
@en
P2093
Andrew J Massey
Andreá Fiumana
Helen Browne
Lisa Baker
Mandy Fallowfield
Mark Christie
Martin J Drysdale
Simon Bedford
P2860
P304
35797-35812
P356
10.18632/ONCOTARGET.5929
P407
P577
2015-09-30T00:00:00Z