Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.
about
Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules.Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1.In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules.Selective alkylation of T-T mismatched DNA using vinyldiaminotriazine-acridine conjugate.
P2860
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P2860
Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
@zh-cn
name
Investigating the binding mode ...... ery of a DNA-selective binder.
@ast
Investigating the binding mode ...... ery of a DNA-selective binder.
@en
type
label
Investigating the binding mode ...... ery of a DNA-selective binder.
@ast
Investigating the binding mode ...... ery of a DNA-selective binder.
@en
prefLabel
Investigating the binding mode ...... ery of a DNA-selective binder.
@ast
Investigating the binding mode ...... ery of a DNA-selective binder.
@en
P2093
P2860
P50
P356
P1433
P1476
Investigating the binding mode ...... ery of a DNA-selective binder.
@en
P2093
Alex M H Lucas
Anne M Baranger
Stacie L Richardson
Yen-Jun Ho
P2860
P304
P356
10.1002/CBIC.201200602
P577
2012-10-24T00:00:00Z