The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.
about
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 systemExploiting a natural conformational switch to engineer an interleukin-2 'superkine'Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytesAdoptive cell transfer: a clinical path to effective cancer immunotherapySafety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvantIL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer CellsInsights into cytokine-receptor interactions from cytokine engineeringStrategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen ModificationProliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaquesViral Vaccines and CTL ResponseCrystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in transCrystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentationInstructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyInflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical ImplicationsAlong the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to MammalsImproving natural killer cell cancer immunotherapyThe shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapyAn evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharidesA nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungsTherapeutic cancer vaccines and combination immunotherapies involving vaccinationLymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and siteOncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frameThe protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functionsMaltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivativesIL-15 expression on RA synovial fibroblasts promotes B cell survivalCancer immunotherapy via dendritic cellsVaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in miceThe A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbitsLeptin and mucosal immunity.In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic diseaseLarge granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9.Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV.Association of interleukin-15-induced peripheral immune activation with hepatic stellate cell activation in persons coinfected with hepatitis C virus and HIV.Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling.Novel human interleukin-15 agonists
P2860
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P2860
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The biology of interleukin-2 a ...... er therapy and vaccine design.
@ast
The biology of interleukin-2 a ...... er therapy and vaccine design.
@en
type
label
The biology of interleukin-2 a ...... er therapy and vaccine design.
@ast
The biology of interleukin-2 a ...... er therapy and vaccine design.
@en
prefLabel
The biology of interleukin-2 a ...... er therapy and vaccine design.
@ast
The biology of interleukin-2 a ...... er therapy and vaccine design.
@en
P356
P1476
The biology of interleukin-2 a ...... er therapy and vaccine design.
@en
P2093
Thomas A Waldmann
P304
P356
10.1038/NRI1901
P577
2006-08-01T00:00:00Z