Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.
about
The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylationEffect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate substrate binding on the structure and function of {gamma}-glutamyl carboxylaseFatal hemorrhage in mice lacking gamma-glutamyl carboxylase.Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiencyVitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylaseIdentification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylationA new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of histidine 160 disrupts glutamic acid carbanion formation and efficient coupling of vitamin K epoxidation to glutamic acid carboxylation.The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation.A conserved region of human vitamin K-dependent carboxylase between residues 393 and 404 is important for its interaction with the glutamate substrate.
P2860
Q28115117-0676BC42-51C1-4DD4-804F-AE3666E08EC7Q34181436-446569F4-2058-4C72-9BD1-54F24AB9E401Q35839891-29E57E4F-B184-489A-9F5C-1A7C4ABA6A36Q35849078-682E6256-1E21-44C1-8128-615CFD066B27Q36828708-883F39F5-77C0-4014-97AC-E2E7E69D541AQ37279415-836DFDFF-51D3-4B67-94D0-2012598A64D7Q37535218-530B9EF4-FC3C-4FCA-9D80-E058A62CA3DDQ41879585-C8CAB103-1248-4CD8-B649-36A962C97D77Q42664012-5245F712-777B-4DD8-9F29-2B70448470F7Q44580839-785C3A91-AFC1-462A-834E-0D9148841905
P2860
Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Propeptide and glutamate-conta ...... n inactive to an active state.
@ast
Propeptide and glutamate-conta ...... n inactive to an active state.
@en
type
label
Propeptide and glutamate-conta ...... n inactive to an active state.
@ast
Propeptide and glutamate-conta ...... n inactive to an active state.
@en
prefLabel
Propeptide and glutamate-conta ...... n inactive to an active state.
@ast
Propeptide and glutamate-conta ...... n inactive to an active state.
@en
P2093
P2860
P356
P1476
Propeptide and glutamate-conta ...... n inactive to an active state.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.17.9069
P407
P577
1997-08-01T00:00:00Z