The catalytic mechanisms of binuclear metallohydrolases.
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Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycleIn Search of Enzymes with a Role in 3', 5'-Cyclic Guanosine Monophosphate Metabolism in PlantsMolecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolaseMalonate-bound structure of the glycerophosphodiesterase fromEnterobacter aerogenes(GpdQ) and characterization of the native Fe2+metal-ion preferenceSubstrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenesComparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal IonThe organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysisThe TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin HomeostasisIdentification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeuticsFluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamicsIron(III) located in the dinuclear metallo-β-lactamase IMP-1 by pseudocontact shiftsDiscovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis.The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosaIdentification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?A novel asymmetric di-Ni(II) system as a highly efficient functional model for phosphodiesterase: synthesis, structures, physicochemical properties and catalytic kinetics.The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics.Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1.Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.Self-activating nuclease and anticancer activities of copper(II) complexes with aryl-modified 2,6-di(thiazol-2-yl)pyridine.Insight into the phosphodiesterase mechanism from combined QM/MM free energy simulations.Optimal level of purple acid phosphatase5 is required for maintaining complete resistance to Pseudomonas syringae.Copper-, palladium-, and platinum-containing complexes of an asymmetric dinucleating ligand.Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active siteExpression and Characterization of a Novel Glycerophosphodiester Phosphodiesterase from Pyrococcus furiosus DSM 3638 That Possesses Lysophospholipase D Activity.Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activityMagnetic circular dichroism study of a dicobalt(II) complex with mixed 5- and 6-coordination: a spectroscopic model for dicobalt(II) hydrolases.Characterization of purple acid phosphatases involved in extracellular dNTP utilization in StylosanthesA molecular description of acid phosphatase.Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes.X-ray absorption spectroscopy of dinuclear metallohydrolases.Metallophosphoesterases: structural fidelity with functional promiscuity.Use of magnetic circular dichroism to study dinuclear metallohydrolases and the corresponding biomimetics.Revisiting bacterial cyclic nucleotide phosphodiesterases: cyclic AMP hydrolysis and beyond.Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents.Manganese, the stress reliever.Diethylalkylsulfonamido(4-methoxyphenyl)methyl)phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors: synthesis accompanied by experimental and molecular modeling assessments.A synthetic pathway for an unsymmetrical N(5)O(2) heptadentate ligand and its heterodinuclear iron(III)zinc(II) complex: a biomimetic model for the purple acid phosphatases.Copper(II) and Zinc(II) Complexes of Conformationally Constrained Polyazamacrocycles as Efficient Catalysts for RNA Model Substrate Cleavage in Aqueous Solution at Physiological pH.Ca(II) Binding Regulates and Dominates the Reactivity of a Transition-Metal-Ion-Dependent Diesterase from Mycobacterium tuberculosis.
P2860
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P2860
The catalytic mechanisms of binuclear metallohydrolases.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The catalytic mechanisms of binuclear metallohydrolases.
@ast
The catalytic mechanisms of binuclear metallohydrolases.
@en
type
label
The catalytic mechanisms of binuclear metallohydrolases.
@ast
The catalytic mechanisms of binuclear metallohydrolases.
@en
prefLabel
The catalytic mechanisms of binuclear metallohydrolases.
@ast
The catalytic mechanisms of binuclear metallohydrolases.
@en
P2093
P50
P356
P1433
P1476
The catalytic mechanisms of binuclear metallohydrolases
@en
P2093
Ademir Neves
Lawrence R Gahan
Sarah J Smith
P304
P356
10.1021/CR050318F
P577
2006-08-01T00:00:00Z