A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity.
about
The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptorsThe dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites.Hooked on benzodiazepines: GABAA receptor subtypes and addiction.Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulationDesformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitZolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface.α4βδ GABAA receptors and tonic inhibitory current during adolescence: effects on mood and synaptic plasticityAlterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of β1 -subunit-containing receptorsThe structural basis of function in Cys-loop receptors.Ligand binding and structural properties of segments of GABAA receptor alpha 1 subunit overexpressed in Escherichia coli.A single amino acid in the second transmembrane domain of GABA rho subunits is a determinant of the response kinetics of GABAC receptors.Mechanism of Allosteric Modulation of the Cys-loop Receptors.Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are differentOn the benzodiazepine binding pocket in GABAA receptors.GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.Discovery of novel insomnia leads from screening traditional Chinese medicine database.Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice.Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation.Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors.A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis.Variations in maternal care alter GABA(A) receptor subunit expression in brain regions associated with fear.Postnatal down-regulation of the GABAA receptor γ2 subunit in neocortical NG2 cells accompanies synaptic-to-extrasynaptic switch in the GABAergic transmission mode.Electrophysiological evidence for the coexistence of alpha1 and alpha6 subunits in a single functional GABA(A) receptor.Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study.
P2860
Q24651488-5192801F-B780-4CBB-AFA3-5DC4229626DCQ30401509-227E2B12-905B-40D7-996A-DFC5E1E4C40AQ33607409-8BA1CAFC-78CC-4E7D-9C04-78B286F93735Q34275459-D56C0C01-58F3-4891-9B7B-B206F5A1D665Q35080531-684852D1-8E69-416A-87A7-C4FF1EEC01FAQ35839008-FCA90A13-11EE-4143-9059-48A2654983D5Q35897805-DB53A65B-4638-484A-8CA5-2B62D4D4963FQ37040099-78884468-FE1B-4F04-A011-AC250F7A3A49Q37138725-FD17B48F-C329-4D45-A526-D5CE30986669Q37169736-72B1DB1B-82D9-43A3-B133-A665EED81F2EQ37789790-EB4DB3A0-F734-419E-9A4A-D36EE388109BQ38313322-A6BBFE9E-4B14-4F7C-BF77-7ABA6BDCF079Q38323030-1213A7B1-CA98-44E4-9F3F-8F41ED9F58F5Q38974419-5C6F486A-940E-4D8A-9FEF-02C437E5DBD5Q39923376-EF5707CC-0BA2-4116-85D4-3142E685E3E9Q40617515-C5CA30FC-6BB8-40EE-8166-A019DF14298DQ41984180-D209011E-F63D-441F-AADD-540A5BE02885Q43413571-7610FC72-8DAA-4181-AF80-1DC6194C69F7Q44845256-7AA89676-426C-4627-8186-C1054FE3DD0EQ45247881-251D5025-80D5-4287-AA40-C0F9C006A560Q46556621-22323531-9E6C-45BD-B5E5-945756ADF460Q46937522-8BEEF710-FA65-4377-9FD9-A01BBCCFA2DDQ48159570-04608161-9F90-4FCD-AA1F-608F4A0488F4Q48239672-42C11CC6-B8F1-4DAE-86B8-4A89CE25DE7FQ48878568-EAE73983-0D29-4C0B-BE7E-35C2A4637538Q48890815-D2835ACC-AA24-4502-81D8-A121CFCEE94DQ53670140-BB943750-B845-49D7-958F-C4BE4D3DABAF
P2860
A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A point mutation in the gamma2 ...... pine binding site specificity.
@ast
A point mutation in the gamma2 ...... pine binding site specificity.
@en
type
label
A point mutation in the gamma2 ...... pine binding site specificity.
@ast
A point mutation in the gamma2 ...... pine binding site specificity.
@en
prefLabel
A point mutation in the gamma2 ...... pine binding site specificity.
@ast
A point mutation in the gamma2 ...... pine binding site specificity.
@en
P2860
P356
P1476
A point mutation in the gamma2 ...... pine binding site specificity.
@en
P2860
P304
P356
10.1073/PNAS.94.16.8824
P407
P577
1997-08-01T00:00:00Z