Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.
about
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression.The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding proteinIsolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition.Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombeThe dynamic association of RCC1 with chromatin is modulated by Ran-dependent nuclear transport.The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.The Ran GTPase cycle is required for yeast nuclear pore complex assembly.The fission yeast ran GTPase is required for microtubule integrity.Nucleocytoplasmic transport of macromoleculesIsolated mammalian and Schizosaccharomyces pombe ran-binding domains rescue S. pombe sbp1 (RanBP1) genomic mutantsThe balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transportSchizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2.Fission yeast Mog1p homologue, which interacts with the small GTPase Ran, is required for mitosis-to-interphase transition and poly(A)(+) RNA metabolism.Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus.Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.
P2860
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P2860
Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@ast
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@en
type
label
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@ast
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@en
prefLabel
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@ast
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@en
P2093
P2860
P356
P1476
Perturbations in the spi1p GTP ...... milar phenotypic consequences.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.11.6352
P407
P577
1996-11-01T00:00:00Z