CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.
about
Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophagesp21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cellsCD28 and CTLA-4 coreceptor expression and signal transductionCD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axisSynergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradationAn enigmatic tail of CD28 signaling.KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes.Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease.CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-RasMechanism responsible for T-cell antigen receptor- and CD28- or interleukin 1 (IL-1) receptor-initiated regulation of IL-2 gene expression by NF-kappaBExpression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responsesDeregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death.Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein.Regulation of immune responses by NF-kappa B/Rel transcription factor.TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation.Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element.Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activationExpression of IκBα in the nucleus of human peripheral blood T lymphocytes
P2860
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P2860
CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@ast
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@en
type
label
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@ast
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@en
prefLabel
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@ast
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@en
P2093
P2860
P356
P1476
CD28 mediates a potent costimu ...... us NF-kappaB/Rel heterodimers.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.12.6736
P407
P577
1996-12-01T00:00:00Z