Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.
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MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityThe interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female miceMutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functionsStructure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase.Functional residues on the surface of the N-terminal domain of yeast Pms1Structure of the MutLĪ± C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease siteFunctional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins.Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast.The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerDNA mismatch repair and mutation avoidance pathwaysDominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathwayDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeA PLAC8-containing protein from an endomycorrhizal fungus confers cadmium resistance to yeast cells by interacting with Mlh3pHuman MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population.Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates.Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae.Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Inactivation of DNA mismatch repair by increased expression of yeast MLH1.Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replicationSynchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndromeSystematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repairNegative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processesMLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiaeThe Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.Modeling of the DNA-binding site of yeast Pms1 by mass spectrometry.Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha.DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.Single molecule studies of DNA mismatch repair.
P2860
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P2860
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.
description
1997 nĆ® lÅ«n-bĆ»n
@nan
1997幓ć®č«ę
@ja
1997幓č«ę
@yue
1997幓č«ę
@zh-hant
1997幓č«ę
@zh-hk
1997幓č«ę
@zh-mo
1997幓č«ę
@zh-tw
1997幓č®ŗę
@wuu
1997幓č®ŗę
@zh
1997幓č®ŗę
@zh-cn
name
Functional domains of the Sacc ...... l cancer-associated mutations.
@ast
Functional domains of the Sacc ...... l cancer-associated mutations.
@en
type
label
Functional domains of the Sacc ...... l cancer-associated mutations.
@ast
Functional domains of the Sacc ...... l cancer-associated mutations.
@en
prefLabel
Functional domains of the Sacc ...... l cancer-associated mutations.
@ast
Functional domains of the Sacc ...... l cancer-associated mutations.
@en
P2093
P2860
P356
P1476
Functional domains of the Sacc ...... l cancer-associated mutations.
@en
P2093
P2860
P304
P356
10.1128/MCB.17.8.4465
P407
P577
1997-08-01T00:00:00Z