Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C
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Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulationMolecular mechanisms and regulation of urinary acidificationProximal nephronCloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal controlThe Concise Guide to PHARMACOLOGY 2013/14: transporters.Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs.Chimeric Na+/H+ exchangers: an epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinasesOverexpression of csk inhibits acid-induced activation of NHE-3.Glucose-induced changes in Na+/H+ antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C.Electrolyte transport in the mammalian colon: mechanisms and implications for disease.Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule.Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation siteEvidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitisPolarized Na+/H+ exchange function is pliable in response to transepithelial gradients of propionateActivation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3.Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule.Acid incubation increases NHE-3 mRNA abundance in OKP cells.The Na⁺/H⁺ exchanger isoform 3 is required for active paracellular and transcellular Ca²⁺ transport across murine cecumCarbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.cAMP-dependent secretagogues stimulate the NaHCO3 cotransporter in the villous epithelium of the brushtail possum, Trichosurus vulpecula.Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3.Acute inhibition of brain-specific Na(+)/H(+) exchanger isoform 5 by protein kinases A and C and cell shrinkage.Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger.Regulation of phagosomal acidification. Differential targeting of Na+/H+ exchangers, Na+/K+-ATPases, and vacuolar-type H+-atpases.Regulation of the epithelial brush border Na+/H+ exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger.Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+/H+ exchange.The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity.Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors.Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3.Inhibition of apical Cl-/OH- exchange activity in Caco-2 cells by phorbol esters is mediated by PKCepsilon.Kinetic dissection of two distinct proton binding sites in Na+/H+ exchangers by measurement of reverse mode reaction.Role of the NHE3 isoform of the Na+/H+ exchanger in sodium absorption by the rabbit gallbladder.Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption.Membrane-limited expression and regulation of Na+-H+ exchanger isoforms by P2 receptors in the rat submandibular gland ductEffects of Protein Kinase C on the Na+-H+ Exchange in the Cochlear Outer Hair Cell
P2860
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P2860
Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Functional characteristics of ...... inhibition by protein kinase C
@ast
Functional characteristics of ...... inhibition by protein kinase C
@en
type
label
Functional characteristics of ...... inhibition by protein kinase C
@ast
Functional characteristics of ...... inhibition by protein kinase C
@en
prefLabel
Functional characteristics of ...... inhibition by protein kinase C
@ast
Functional characteristics of ...... inhibition by protein kinase C
@en
P2093
P2860
P356
P1476
Functional characteristics of ...... inhibition by protein kinase C
@en
P2093
J Pouyssegur
M Donowitz
M H Montrose
S A Levine
P2860
P304
P356
10.1073/PNAS.90.19.9110
P407
P577
1993-10-01T00:00:00Z