Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability
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Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblastsHuman Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubulesImmortality of cell lines: challenges and advantages of establishmentA box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' endYeast telomerase is specialized for C/A-rich RNA templates.Rapid telomere motions in live human cells analyzed by highly time-resolved microscopyHuman telomerase RNA template sequence is a determinant of telomere repeat extension rate.Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo.Expression of mutated Paramecium telomerase RNAs in vivo leads to templating errors that resemble those made by retroviral reverse transcriptase.Molecular basis for telomere repeat divergence in budding yeastTelomeric recombination induced by dysfunctional telomeres.Dynamics of telomeric DNA turnover in yeast.Specific telomerase RNA residues distant from the template are essential for telomerase function.The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.Molecular targeting of cancer: telomeres as targets.A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferationQuantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cellsTelomerase inhibition in cancer therapeutics: molecular-based approachesInhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death.Telomere biology of pediatric cancer.In situ visualization of telomere elongation patterns in human cells.Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.Three telomerases with completely non-telomeric template replacements are catalytically active.Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability.A human telomerase-associated nuclease.Evolution of the Arabidopsis telomerase RNA.ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells."Poisoning" yeast telomeres distinguishes between redundant telomere capping pathways.
P2860
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P2860
Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Reprogramming of telomerase by ...... te with reduced cell viability
@ast
Reprogramming of telomerase by ...... te with reduced cell viability
@en
type
label
Reprogramming of telomerase by ...... te with reduced cell viability
@ast
Reprogramming of telomerase by ...... te with reduced cell viability
@en
prefLabel
Reprogramming of telomerase by ...... te with reduced cell viability
@ast
Reprogramming of telomerase by ...... te with reduced cell viability
@en
P2093
P2860
P356
P1476
Reprogramming of telomerase by ...... te with reduced cell viability
@en
P2093
P2860
P304
P356
10.1128/MCB.17.11.6394
P407
P577
1997-11-01T00:00:00Z