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Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionNew insights into the mechanisms of Treg functionHomeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic TregsUbiquitin-dependent regulation of Foxp3 and Treg functionIn-situ tumor vaccination: Bringing the fight to the tumorTreg functional stability and its responsiveness to the microenvironmentOrgan-specific and memory treg cells: specificity, development, function, and maintenanceUbiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified PigsCD45 ligation expands Tregs by promoting interactions with DCsCD28-CD80 interactions control regulatory T cell motility and immunological synapse formation.Ubiquitous points of control over regulatory T cells.Alloantigen-specific regulatory T cells generated with a chimeric antigen receptorRegulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stabilityCell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice.IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation.Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cellsDeletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin HomingNovel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production.Targeting Treg signaling for the treatment of autoimmune diseasesPeripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and functionComprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer.MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cellsReduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditisImmunomics in Skin Cancer - Improvement in Diagnosis, Prognosis and Therapy Monitoring.Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to ModelsDual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells.Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis.Emerging Co-signaling Networks in T Cell Immune Regulation.T-cell costimulatory blockade in organ transplantation.Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.New insights into T-cell cosignaling in allograft rejection and survival.Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance.Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
An obligate cell-intrinsic function for CD28 in Tregs
@ast
An obligate cell-intrinsic function for CD28 in Tregs
@en
type
label
An obligate cell-intrinsic function for CD28 in Tregs
@ast
An obligate cell-intrinsic function for CD28 in Tregs
@en
prefLabel
An obligate cell-intrinsic function for CD28 in Tregs
@ast
An obligate cell-intrinsic function for CD28 in Tregs
@en
P2093
P2860
P356
P1476
An obligate cell-intrinsic function for CD28 in Tregs
@en
P2093
Alexandria Huynh
Gregory Whitcher
Jihoon Chang
Jonathan S Maltzman
Laurence A Turka
Ruan Zhang
P2860
P304
P356
10.1172/JCI65013
P407
P577
2013-01-02T00:00:00Z