High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
about
FES kinases are required for oncogenic FLT3 signalingThe MET axis as a therapeutic target.DNA sequencing of a cytogenetically normal acute myeloid leukaemia genomeGenetic characterization of TET1, TET2, and TET3 alterations in myeloid malignanciesClass III Receptor Tyrosine Kinases in Acute Leukemia - Biological Functions and Modern Laboratory AnalysisIGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting.Sequence and structure signatures of cancer mutation hotspots in protein kinasesA rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes.What are the endpoints of therapy for acute leukemias? Old definitions and new challenges.Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasiaCancer driver mutations in protein kinase genesMET receptor sequence variants R970C and T992I lack transforming capacity.Mutated genes, pathways and processes in tumours.Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemiaRapid Identification of Therapeutic Targets in Hematologic Malignancies via Functional Genomics.MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell contextA phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemiaThe role of the c-Met pathway in lung cancer and the potential for targeted therapy.Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemiaOur changing view of the genomic landscape of cancer.Molecular damage in cancer: an argument for mTOR-driven agingDiscoidin domain receptor tyrosine kinases: new players in cancer progressionMutational heterogeneity in human cancers: origin and consequences.SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML.Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosisA decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.High-affinity neurotrophin receptors and ligands promote leukemogenesis.The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.From cancer genomes to cancer models: bridging the gapsRNAi screen for rapid therapeutic target identification in leukemia patients.JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesDescription of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects.Cancer genome sequencing--an interim analysis.Systematic genomic screen for tyrosine kinase mutations in CLL.Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation.
P2860
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P2860
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@ast
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@en
type
label
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@ast
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@en
prefLabel
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@ast
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@en
P2093
P2860
P50
P1433
P1476
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
@en
P2093
Benjamin Lee
Christopher A Eide
Claudia Scholl
D Gary Gilliland
Eric P Stoffregen
Gerlinde Wernig
Heidi Erickson
James D Griffin
Marc M Loriaux
Michael W Deininger
P2860
P304
P356
10.1182/BLOOD-2007-07-101394
P407
P577
2008-02-05T00:00:00Z