Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: general concepts.
about
Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data.Optimizing the data combination rule for seamless phase II/III clinical trials.Toxicologic pathology in the 21st century.Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: a multicentre, randomised, blinded, controlled and non-inferiority trial.Sample size re-assessment leading to a raised sample size does not inflate type I error rate under mild conditions.Advances in Statistical Approaches Oncology Drug Development.Design issues in randomized phase II/III trials.Closed Testing in Pharmaceutical Research: Historical and Recent DevelopmentsAdaptive design of confirmatory trials: Advances and challenges.Adaptive seamless designs: selection and prospective testing of hypotheses.A dose-ranging study of tiotropium delivered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.Seamless Phase IIa/IIb and enhanced dose-finding adaptive design.PIPELINEs: Creating Comparable Clinical Knowledge Efficiently by Linking Trial Platforms.Physiotherapy Rehabilitation for Osteoporotic Vertebral Fracture (PROVE): study protocol for a randomised controlled trial.Seamless phase II/III designs.Group-sequential methods for adaptive seamless phase II/III clinical trials.Integrating predictive biomarkers and classifiers into oncology clinical development programmes.Designing studies to find early signals of efficacy.Integrated phase II/III clinical trials in oncology: a case study.A comparison of methods for constructing confidence intervals after phase II/III clinical trials.Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial.Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls.Simple sequential boundaries for treatment selection in multi-armed randomized clinical trials with a control.Point estimation in adaptive enrichment designs.Investigating interventions to increase uptake of HIV testing and linkage into care or prevention for male partners of pregnant women in antenatal clinics in Blantyre, Malawi: study protocol for a cluster randomised trial.Decision-theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta-binomial distribution.Optimizing drug development in oncology by clinical trial simulation: Why and how?A modified varying-stage adaptive phase II/III clinical trial design.Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules.Group sequential designs with prospectively planned rules for subpopulation enrichment.Multiple testing procedures for adaptive enrichment designs: combining group sequential and reallocation approaches.A simple and flexible graphical approach for adaptive group-sequential clinical trials.A Hybrid Geometric Phase II/III Clinical Trial Design based on Treatment Failure Time and Toxicity.Testing multiple primary endpoints in clinical trials with sample size adaptation.Estimation after subpopulation selection in adaptive seamless trials.An adaptive two-stage dose-response design method for establishing proof of conceptA comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints.Confidence intervals for confirmatory adaptive two-stage designs with treatment selection.A multi-stage drop-the-losers design for multi-arm clinical trials.Interim analyses in diagnostic versus treatment studies: differences and similarities
P2860
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P2860
Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: general concepts.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Confirmatory seamless phase II ...... at interim: general concepts.
@ast
Confirmatory seamless phase II ...... at interim: general concepts.
@en
type
label
Confirmatory seamless phase II ...... at interim: general concepts.
@ast
Confirmatory seamless phase II ...... at interim: general concepts.
@en
prefLabel
Confirmatory seamless phase II ...... at interim: general concepts.
@ast
Confirmatory seamless phase II ...... at interim: general concepts.
@en
P2093
P356
P1433
P1476
Confirmatory seamless phase II ...... at interim: general concepts.
@en
P2093
Amy Racine
Heinz Schmidli
Willi Maurer
P304
P356
10.1002/BIMJ.200510232
P577
2006-08-01T00:00:00Z