Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors
about
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteriaRlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNAPotential role of tedizolid phosphate in the treatment of acute bacterial skin infectionsResistance to linezolid caused by modifications at its binding site on the ribosomeStructural Basis for Methyl Transfer by a Radical SAM EnzymeCrystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNATargeting Antibiotic ResistanceBiochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN MethyltransferasesTedizolid Phosphate: a Next-Generation Oxazolidinone.Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing.High prevalence of Cfr-producing Staphylococcus species in retail meat in Guangzhou, ChinaIdentification of the multi-resistance gene cfr in Escherichia coli isolates of animal origin.The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.Antibiotics and bacterial resistance in the 21st century.A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene.Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Low fitness cost of the multidrug resistance gene cfr.[Resistance to "last resort" antibiotics in Gram-positive cocci: The post-vancomycin era].First report of the multidrug resistance gene cfr in Enterococcus faecalis of animal originTransferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalisThe order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance geneTransferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment.The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147LCfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus.Structural basis for cross-resistance to ribosomal PTC antibiotics.First report of the multiresistance gene cfr in Streptococcus suis.Tools for characterizing bacterial protein synthesis inhibitors.Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Radical S-adenosylmethionine enzymes: mechanism, control and function.The oxazolidinones: past, present, and future.The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.Key genetic elements and regulation systems in methicillin-resistant Staphylococcus aureus.Speculative strategies for new antibacterials: all roads should not lead to Rome.Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin.Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.Linezolid Resistance in Staphylococci.Characterization of novel conjugative multiresistance plasmids carrying cfr from linezolid-resistant Staphylococcus epidermidis clinical isolates from Italy.Genetic environment of the transferable oxazolidinone/phenicol resistance gene optrA in Enterococcus faecalis isolates of human and animal origin.
P2860
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P2860
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Transcriptional and translatio ...... f protein synthesis inhibitors
@ast
Transcriptional and translatio ...... f protein synthesis inhibitors
@en
type
label
Transcriptional and translatio ...... f protein synthesis inhibitors
@ast
Transcriptional and translatio ...... f protein synthesis inhibitors
@en
prefLabel
Transcriptional and translatio ...... f protein synthesis inhibitors
@ast
Transcriptional and translatio ...... f protein synthesis inhibitors
@en
P2860
P356
P1476
Transcriptional and translatio ...... f protein synthesis inhibitors
@en
P2093
Alexander S Mankin
Lisa K Smith
P2860
P304
P356
10.1128/AAC.01583-07
P407
P577
2008-02-25T00:00:00Z