Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. - Wikidata - awgldk - TriplyDB

Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.

Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.

http://www.wikidata.org/entity/Q36593985

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Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR)Central control of body temperature Induction of therapeutic hypothermia by pharmacological modulation of temperature-sensitive TRP channels: theoretical framework and practical considerations Species-specific temperature sensitivity of TRPA1 TRPM3 in temperature sensing and beyond TRP ion channels in thermosensation, thermoregulation and metabolism VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.Spinal cord thermosensitivity: An afferent phenomenon?Molecular mechanisms of temperature adaptation Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution Neural Signaling Metabolites May Modulate Energy Use in Hibernation.Skin temperature: its role in thermoregulation In vivo correlates of thermoregulatory defense in humans: Temporal course of sub-cortical and cortical responses assessed with fMRI.Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine.Local daily temperatures, thermal seasons, and suicide rates in Finland from 1974 to 2010.Cold-Induced Thermogenesis and Inflammation-Associated Cold-Seeking Behavior Are Represented by Different Dorsomedial Hypothalamic Sites: A Three-Dimensional Functional Topography Study in Conscious Rats The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8 AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP Central nervous system regulation of brown adipose tissue.Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache Current understanding on the neurophysiology of behavioral thermoregulation."Science without Borders" program and Brazilian-Hungarian collaboration in thermoregulation.Brazil: What country is this?The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol.An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways Lipopolysaccharide-induced neuronal activation in the paraventricular and dorsomedial hypothalamus depends on ambient temperature.Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis.Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.TRPM8 and Migraine Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes.Genes, molecules and patients--emerging topics to guide clinical pain research.TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality?A vascular mechanistic approach to understanding Raynaud phenomenon.Emerging drugs for overactive bladder.Body Temperature Measurements for Metabolic Phenotyping in Mice.Involvement of thermosensitive TRP channels in energy metabolism.

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Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.

http://www.wikidata.org/entity/Q36593985

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Pharmacological blockade of th ...... creases deep body temperature.

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Journal of Neuroscience

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Andrej A Romanovsky

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Daniela L Oliveira

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Diana Bautista

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Judy Wang

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M Camila Almeida

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Narender R Gavva

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Nuria Tamayo

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Prafulla Aryal

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Renato N Soriano

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Sara Rao

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P2860

Clinical practice. Acute ischemic stroke

Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors

Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice

The menthol receptor TRPM8 is the principal detector of environmental cold

TRPM8 is required for cold sensation in mice

A TRP channel that senses cold stimuli and menthol

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

Attenuated cold sensitivity in TRPM8 null mice

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia

Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia

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2086-2099

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10.1523/JNEUROSCI.5606-11.2012

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6

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Tamara Hew-Butler

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2012-02-01T00:00:00Z

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22323721

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3566779

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