about
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicalsAsparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1Identification of a poxvirus gene encoding a uracil DNA glycosylaseIsolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutantsStructure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase betaEarly steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsHuman AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability.The current state of eukaryotic DNA base damage and repairBase excision repair and cancerDNA apurinic-apyrimidinic site binding and excision by endonuclease IVStructure of the endonuclease IV homologue fromThermotoga maritimain the presence of active-site divalent metal ionsCharacterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function.Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidineMolecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extractsBiphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylaseDistinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanineThe global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosaPurification and characterization of human 3-methyladenine-DNA glycosylaseSpecific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testisThe GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk.Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities.Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.Apurinic/apyrimidinic endonucleases of Mycobacterium tuberculosis protect against DNA damage but are dispensable for the growth of the pathogen in guinea pigs.Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsPurification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3'-repair diesterase.Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII.Substrate channeling in mammalian base excision repair pathways: passing the batonThe post-incision steps of the DNA base excision repair pathway in Escherichia coli: studies with a closed circular DNA substrate containing a single U:G base pairDual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expressionThe redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domainsEndonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damageCysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA bindingA review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways.
P2860
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P2860
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
The enzymology of apurinic/apyrimidinic endonucleases.
@ast
The enzymology of apurinic/apyrimidinic endonucleases.
@en
type
label
The enzymology of apurinic/apyrimidinic endonucleases.
@ast
The enzymology of apurinic/apyrimidinic endonucleases.
@en
prefLabel
The enzymology of apurinic/apyrimidinic endonucleases.
@ast
The enzymology of apurinic/apyrimidinic endonucleases.
@en
P1433
P1476
The enzymology of apurinic/apyrimidinic endonucleases.
@en
P2093
Cunningham RP
Doetsch PW
P304
P356
10.1016/0921-8777(90)90004-O
P407
P577
1990-09-01T00:00:00Z