The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements
about
Long-Range Regulation of V(D)J RecombinationThe ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusionEpigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes.Spatio-temporal regulation of RAG2 following genotoxic stress.High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX.RAG Represents a Widespread Threat to the Lymphocyte Genome.RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks.MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA.Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.Mechanisms of central tolerance for B cells.V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity.The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.Ataxia telangiectasia syndrome: moonlighting ATM.Tel1(ATM)-mediated interference suppresses clustered meiotic double-strand-break formation.
P2860
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P2860
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@ast
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@en
type
label
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@ast
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@en
prefLabel
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@ast
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@en
P2093
P2860
P356
P1476
The ataxia telangiectasia muta ...... ondary Vκ-to-Jκ rearrangements
@en
P2093
Baeck-Seung Lee
Barry P Sleckman
Craig H Bassing
David G Schatz
Emily Schulte
Jeffrey J Bednarski
Katherine S Yang-Iott
Natalie C Steinel
P2860
P304
P356
10.1084/JEM.20121605
P407
P577
2013-02-04T00:00:00Z