In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery.
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Potential in vitro model for testing the effect of exposure to nanoparticles on the lung alveolar epithelial barrierA physiologically-motivated compartment-based model of the effect of inhaled hypertonic saline on mucociliary clearance and liquid transport in cystic fibrosisDelivery of RNAi Therapeutics to the Airways-From Bench to BedsideToxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studiesAerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery SystemsTranslocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experimentsIn Vivo Toxicity Studies of Metal and Metal Oxide NanoparticlesAt the biological modeling and simulation frontier.Embryonic chicken trachea as a new in vitro model for the investigation of mucociliary particle clearance in the airwaysConjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin.Nanomedicine in pulmonary deliveryPolymeric nanocarriers for transport modulation across the pulmonary epithelium: dendrimers, polymeric nanoparticles, and their nanoblendsSafety of prolonged, repeated administration of a pulmonary formulation of tissue plasminogen activator in micePK10453, a nonselective platelet-derived growth factor receptor inhibitor, prevents the progression of pulmonary arterial hypertension.Efficient intratracheal delivery of airway epithelial cells in mice and pigsAdenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearanceNovel aspects of pathogenesis and regeneration mechanisms in COPDCan Patients with Parkinson's Disease Use Dry Powder Inhalers during Off Periods?Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells.Human Airway Primary Epithelial Cells Show Distinct Architectures on Membrane Supports Under Different Culture Conditions.Inhalative nanomedicine--opportunities and challenges.Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal Model.Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties.Preclinical models for pulmonary drug delivery.In vitro and in vivo testing methods for respiratory drug delivery.Strategies for non-invasive delivery of biologics.The development of models for the evaluation of pulmonary drug disposition.Pharmaceutical applications of the Calu-3 lung epithelia cell line.Mechanisms of absorption and elimination of drugs administered by inhalation.Lactose engineering for better performance in dry powder inhalers.Nanoparticle-mediated pulmonary drug delivery: a reviewBioavailability of therapeutic proteins by inhalation--worker safety aspects.The role of particle physico-chemical properties in pulmonary drug delivery for tuberculosis therapy.Inhalable nanocomposite microparticles: preparation, characterization and factors affecting formulation.Antibacterial Loaded Spray Dried Chitosan Polyelectrolyte Complexes as Dry Powder Aerosol for the Treatment of Lung InfectionsEndocytic Uptake, Transport and Macromolecular Interactions of Anionic PAMAM Dendrimers within Lung Tissue.Drug Permeation Characterization of Inhaled Dry Powder Formulations in Air-Liquid Interfaced Cell Layer Using an Improved, Simple Apparatus for Dispersion.Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441.Pharmacokinetic evaluation of tissue distribution of pirfenidone and its metabolites for idiopathic pulmonary fibrosis therapy.Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay.
P2860
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P2860
In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@ast
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@en
type
label
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@ast
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@en
prefLabel
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@ast
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@en
P1476
In vivo, in vitro and ex vivo ...... peutics for systemic delivery.
@en
P2093
Masahiro Sakagami
P304
P356
10.1016/J.ADDR.2006.07.012
P407
P577
2006-08-15T00:00:00Z