Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells - Wikidata - awgldk - TriplyDB

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells

http://www.wikidata.org/entity/Q36610877

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Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells Structure, evolution, and biology of the MUC4 mucin Mucins in cancer: function, prognosis and therapy Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: applications in diagnosis and therapy Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer.TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer.MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity.Prognostic value of mucin 4 expression in colorectal adenocarcinomas.The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways Nucleotide variability and linkage disequilibrium patterns in the porcine MUC4 gene.MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells.Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedb MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells Genetically engineered mucin mouse models for inflammation and cancer.Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation.Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1.MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer.MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells.Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer.MUC4, a multifunctional transmembrane glycoprotein, induces oncogenic transformation of NIH3T3 mouse fibroblast cells.Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin.Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines.Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas.Mucins and pancreatic cancer.MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma.Mucins in pancreatic cancer: biological role, implications in carcinogenesis and applications in diagnosis and therapy.Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas.Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer.Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer.MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.A Census of Tandemly Repeated Polymorphic Loci in Genic Regions Through the Comparative Integration of Human Genome Assemblies.

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P2860

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells

http://www.wikidata.org/entity/Q36610877

description

2007 nî lūn-bûn

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British Journal of Cancer

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Human MUC4 mucin induces ultra ...... ity in pancreatic cancer cells

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P2093

G C Varshney

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J L Meza

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J-P Aubert

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P Chaturvedi

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S K Batra

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P2860

Human MUC4 mucin cDNA and its variants in pancreatic carcinoma

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat array

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation.

Content of mitochondrial DNA and of three mitochondrial RNAs in developing and adult rat cerebellum

Mitochondria and apoptosis

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization.

Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs.

Mitochondria and cell death. Mechanistic aspects and methodological issues.

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345-357

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10.1038/SJ.BJC.6603868

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3

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97

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Nicolas Moniaux

Jorge Rodriguez-Sierra

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6241150

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17595659

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2360313

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