Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
about
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphologyOrganophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatumIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenThe role of ventral striatal cAMP signaling in stress-induced behaviors.Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injuryp120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's diseaseSchizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.Striatal signal transduction and drug addictionDifferential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesisHippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways.Memory enhancement by targeting Cdk5 regulation of NR2B.The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.A new treatment for cognitive disorders related to in utero exposure to alcohol.Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach.A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.The molecular and cellular biology of enhanced cognition.The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - RoscovitinePhosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPasesCyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons.Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine.Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases.Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons.A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn.Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral StriatumHIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic RemodelingCrosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's DiseaseSelenomethionine Ameliorates Neuropathology in the Olfactory Bulb of a Triple Transgenic Mouse Model of Alzheimer's DiseaseThe interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35.Special Issue on "Cdk5 and Brain Disorders": PrologueThe neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.Silencing of CDK5 as potential therapy for Alzheimer's disease.Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease.Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.Targeting Cdk5 activity in neuronal degeneration and regeneration.Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment.Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats.Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications.Cdk5 Is Essential for Amphetamine to Increase Dendritic Spine Density in Hippocampal Pyramidal Neurons.
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P2860
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
@ast
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
@en
type
label
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
@ast
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
@en
prefLabel
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
@ast
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
@en
P2860
P1476
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory
@en
P2093
Marco Angelo
P2860
P304
P356
10.1111/J.1471-4159.2006.04040.X
P407
P577
2006-10-01T00:00:00Z