Acidic pH increases airway surface liquid viscosity in cystic fibrosis - Wikidata - awgldk - TriplyDB

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

http://www.wikidata.org/entity/Q36618542

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pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Diffusion through Pig Gastric Mucin: Effect of Relative Humidity Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel.Aspergillosis and the role of mucins in cystic fibrosis Gel-forming mucins form distinct morphologic structures in airways Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense.Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies Repurposing tromethamine as inhaled therapy to treat CF airway disease.CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes Role of CFTR in epithelial physiology.Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways The Mucus Barrier to Inhaled Gene Therapy.Gene delivery to the lungs: pulmonary gene therapy for cystic fibrosis.Acidosis increases the susceptibility of respiratory epithelial cells to Pseudomonas aeruginosa-induced cytotoxicity.Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography.Strategies for the etiological therapy of cystic fibrosis.Use of ferrets for electrophysiologic monitoring of ion transport.Airway surface liquid pH is not acidic in children with cystic fibrosis.An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.Solitary Cholinergic Stimulation Induces Airway Hyperreactivity and Transcription of Distinct Pro-inflammatory Pathways.Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing.Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling.Imaging viscosity of intragranular mucin matrix in cystic fibrosis cells.Development of an airway mucus defect in the cystic fibrosis rat.Physicochemical properties of mucus and their impact on transmucosal drug delivery.Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation.Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.ATP12A promotes mucus dysfunction during Type 2 airway inflammation.SPX-101 Is a Promising and Novel Nebulized ENaC Inhibitor.Thymosin α1: a single drug with multiple targets in cystic fibrosis.Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology.Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease.Molecular basis of cystic fibrosis: from bench to bedside Mucins: the frontline defence of the lung Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus

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P2860

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

http://www.wikidata.org/entity/Q36618542

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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type

label

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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P1433

Journal of Clinical Investigation

P1476

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

@en

P2093

Ajit Varki

http://www.w3.org/2001/XMLSchema#string

Biswa Choudhury

http://www.w3.org/2001/XMLSchema#string

James D McMenimen

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Mark J Hoegger

http://www.w3.org/2001/XMLSchema#string

Michael J Welsh

http://www.w3.org/2001/XMLSchema#string

Philip H Karp

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Thomas O Moninger

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Xiao Xiao Tang

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P2860

Secretion properties, clearance, and therapy in airway disease

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin

Micro- and macrorheology of mucus

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

Origins of cystic fibrosis lung disease

Endogenous airway acidification. Implications for asthma pathophysiology.

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis.

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10.1172/JCI83922

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3

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126

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Lynda S Ostedgaard

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2016-01-25T00:00:00Z

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26808501

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cystic fibrosis

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4767348

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