Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.

Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.

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http://www.wikidata.org/entity/Q36619992
Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulationStructure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional ImplicationsSuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations.Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptorComputationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 ReceptorMolecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi.The predicted ensemble of low-energy conformations of human somatostatin receptor subtype 5 and the binding of antagonists.Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.The G protein Gi1 exhibits basal coupling but not preassembly with G protein-coupled receptors.Conformational and Thermodynamic Landscape of GPCR Activation from Theory and Computation.
P2860

Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.

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http://www.wikidata.org/entity/Q36619992
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Molecular basis for dramatic c ...... le and double point mutations.
@ast
Molecular basis for dramatic c ...... le and double point mutations.
@en
type
label
Molecular basis for dramatic c ...... le and double point mutations.
@ast
Molecular basis for dramatic c ...... le and double point mutations.
@en
prefLabel
Molecular basis for dramatic c ...... le and double point mutations.
@ast
Molecular basis for dramatic c ...... le and double point mutations.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Molecular basis for dramatic c ...... le and double point mutations.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932