Post-translational modifications in the context of therapeutic proteins.
about
Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signalingHuman immunoglobulin allotypes: possible implications for immunogenicityPosttranslational Modifications and the Immunogenicity of BiotherapeuticsHib Vaccines: Past, Present, and Future PerspectivesFc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeuticsSite-specific functionalization of proteins and their applications to therapeutic antibodiesProtein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profilesCell factories for insulin productionTotal synthesis of glycosylated proteinsOptimized signal peptides for the development of high expressing CHO cell linesDevelopment of a novel ER stress based selection system for the isolation of highly productive clonesSortilin mediates vascular calcification via its recruitment into extracellular vesiclesRapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibodyGlycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic propertiesPurification of derivatized oligosaccharides by solid phase extraction for glycomic analysisA Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug EffectsiSNO-AAPair: incorporating amino acid pairwise coupling into PseAAC for predicting cysteine S-nitrosylation sites in proteinsAlgae as protein factories: expression of a human antibody and the respective antigen in the diatom Phaeodactylum tricornutumIntraclonal protein expression heterogeneity in recombinant CHO cellsForcefield_PTM:Ab InitioCharge and AMBER Forcefield Parameters for Frequently Occurring Post-Translational ModificationsSerum Glycopatterns as Novel Potential Biomarkers for Diagnosis of Acute-on-Chronic Hepatitis B Liver FailureInfluence of glycosylation pattern on the molecular properties of monoclonal antibodies.Post-translational modifications differentially affect IgG1 conformation and receptor binding.Chemical Synthesis of Glycoproteins with the Specific Installation of Gradient-Enriched 15 N-Labeled Amino Acids for Getting Insights into Glycoprotein Behavior.GlycoProfileAssigner: automated structural assignment with error estimation for glycan LC data.High-throughput profiling of N-linked oligosaccharides in therapeutic antibodies using a microfluidic CD platform and MALDI-MS.Prediction of mucin-type O-glycosylation sites in mammalian proteins using the composition of k-spaced amino acid pairsSmall-molecule microarrays as tools in ligand discovery.Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometryIdentification of N-glycan serum markers associated with hepatocellular carcinoma from mass spectrometry data.Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation.High throughput quantification of N-glycans using one-pot sialic acid modification and matrix assisted laser desorption ionization time-of-flight mass spectrometryResolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approachesDual modifications strategy to quantify neutral and sialylated N-glycans simultaneously by MALDI-MS.Alterations in glycopeptides associated with herceptin treatment of human breast carcinoma mcf-7 and T-lymphoblastoid cellstrans,trans-2,4-Hexadiene incorporation on enzymes for site-specific immobilization and fluorescent labeling.Bacterial display and screening of posttranslationally thioether-stabilized peptides.Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contextsCell culture processes for monoclonal antibody production.Glycosylation and disulfide bond analysis of transiently and stably expressed clade C HIV-1 gp140 trimers in 293T cells identifies disulfide heterogeneity present in both proteins and differences in O-linked glycosylation
P2860
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P2860
Post-translational modifications in the context of therapeutic proteins.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Post-translational modifications in the context of therapeutic proteins.
@ast
Post-translational modifications in the context of therapeutic proteins.
@en
type
label
Post-translational modifications in the context of therapeutic proteins.
@ast
Post-translational modifications in the context of therapeutic proteins.
@en
prefLabel
Post-translational modifications in the context of therapeutic proteins.
@ast
Post-translational modifications in the context of therapeutic proteins.
@en
P2860
P356
P1433
P1476
Post-translational modifications in the context of therapeutic proteins.
@en
P2093
Gary Walsh
Roy Jefferis
P2860
P2888
P304
P356
10.1038/NBT1252
P577
2006-10-01T00:00:00Z
P5875
P6179
1033656955