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Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in ObesityBrowning and Graying: Novel Transcriptional Regulators of Brown and Beige Fat Tissues and AgingRecent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plantsMolecular Analysis of Chinese Celastrus and Tripterygium and Implications in Medicinal and Pharmacological StudiesMedicinal plants for the treatment of obesity: ethnopharmacological approach and chemical and biological studies.Melanocortin neurons: Multiple routes to regulation of metabolism.Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications.Gut-Brain Cross-Talk in Metabolic Control.The cellular and molecular bases of leptin and ghrelin resistance in obesity.Anti-obesogenic and antidiabetic effects of plants and mushrooms.The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMsLeptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic WomenSafety Profiles of Tripterygium wilfordii Hook F: A Systematic Review and Meta-Analysis.Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.High motivation for exercise is associated with altered chromatin regulators of monoamine receptor gene expression in the striatum of selectively bred mice.Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway.Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic RatsSalidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus.TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus.Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophages.Celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats.Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells.Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1.The Leptin Receptor Complex: Heavier Than Expected?Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses.Discovery of novel therapeutic properties of drugs from transcriptional responses based on multi-label classification.New therapeutic approaches for the treatment of obesity.Modulation of leptin resistance by food compounds.Renaissance of leptin for obesity therapy.The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies.Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway.Integrative Approaches for the Identification and Localization of Specialized Metabolites in Tripterygium Roots.Celastrol: A Spectrum of Treatment Opportunities in Chronic DiseasesCelastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway.Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin ActionsThe glucoregulatory actions of leptin.Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation.Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetesPolygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles.Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Treatment of obesity with celastrol
@ast
Treatment of obesity with celastrol
@en
type
label
Treatment of obesity with celastrol
@ast
Treatment of obesity with celastrol
@en
prefLabel
Treatment of obesity with celastrol
@ast
Treatment of obesity with celastrol
@en
P2093
P2860
P1433
P1476
Treatment of obesity with celastrol
@en
P2093
Mario Andres Salazar Hernandez
Ralph Mazitschek
Umut Ozcan
P2860
P304
P356
10.1016/J.CELL.2015.05.011
P407
P577
2015-05-01T00:00:00Z