PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1
about
The structural basis for the oligomerization of the N-terminal domain of SATB1Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1.Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation.Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism.The Compass-like locus, exclusive to the Ambulacrarians, encodes a chromatin insulator binding protein in the sea urchin embryo.The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTRSATB homeobox proteins regulate trophoblast stem cell renewal and differentiationSIRT1 deacetylates SATB1 to facilitate MAR HS2-MAR ε interaction and promote ε-globin expression.Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair.Chromatin organizer SATB1 is an important determinant of T-cell differentiation.The role of SATB1 in breast cancer pathogenesis.Tetramerization of SATB1 is essential for regulating of gene expression.Thermodynamic pathways to genome spatial organization in the cell nucleus.N-terminal PDZ-like domain of chromatin organizer SATB1 contributes towards its function as transcription regulator.
P2860
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P2860
PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@ast
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@en
type
label
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@ast
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@en
prefLabel
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@ast
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@en
P2093
P2860
P356
P1476
PDZ domain-mediated dimerizati ...... -affinity DNA binding by SATB1
@en
P2093
Debashis Mitra
K N Ganesh
P Pavan Kumar
Sanjeev Galande
Sunita Singh
P2860
P304
P356
10.1093/NAR/GKM1151
P407
P577
2008-01-10T00:00:00Z