Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
about
CRISPR guide RNA design for research applicationsGenome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screensGenome editing and the next generation of antiviral therapy.Genome Editing with CRISPR-Cas9: Can It Get Any Better?Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration.CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy.Genome-wide target specificities of CRISPR RNA-guided programmable deaminases.Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.Therapeutic applications of CRISPR RNA-guided genome editing.New traits in crops produced by genome editing techniques based on deletionsGene Therapy in Tyrosinemia: Potential and Pitfalls.In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques.Genome editing in maize directed by CRISPR-Cas9 ribonucleoprotein complexes.Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells.Correction of a pathogenic gene mutation in human embryos.A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action.Efficient genome engineering approaches for the short-lived African turquoise killifish.CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects.The Conspicuity of CRISPR-Cpf1 System as a Significant Breakthrough in Genome Editing.In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease.Genome editing reveals a role for OCT4 in human embryogenesis.CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets.Control of gene editing by manipulation of DNA repair mechanisms.A highly specific SpCas9 variant is identified by in vivo screening in yeast.Digenome-seq web tool for profiling CRISPR specificity.Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats.Long Terminal Repeat CRISPR-CAR-Coupled "Universal" T Cells Mediate Potent Anti-leukemic Effects.CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis.Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration.Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells.CRISPR therapeutic tools for complex genetic disorders and cancer (Review).DeepCRISPR: optimized CRISPR guide RNA design by deep learning.Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation.Directed evolution of CRISPR-Cas9 to increase its specificityCRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parametersPairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells
P2860
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P2860
Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@ast
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@en
type
label
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@ast
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@en
prefLabel
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@ast
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@en
P2093
P2860
P356
P1433
P1476
Genome-wide target specificiti ...... aled by multiplex Digenome-seq
@en
P2093
Daesik Kim
Jeongbin Park
Sojung Kim
Sunghyun Kim
P2860
P304
P356
10.1101/GR.199588.115
P50
P577
2016-01-19T00:00:00Z