IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation.
about
Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell VaccinationRegulating the immune system via IL-15 transpresentationOverlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functionsRole of the intestinal cytokine microenvironment in shaping the intraepithelial lymphocyte repertoireThe shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapyIntramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cellsDistinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice.IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors.IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cellsIL-15: a central regulator of celiac disease immunopathology.Natural Killer Cell Functions during the Innate Immune Response to Pathogenic Streptococci.Deciphering the role of DC subsets in MCMV infection to better understand immune protection against viral infectionsIL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo.In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasisDysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication.Interleukin-15 treatment induces weight loss independent of lymphocytes.Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus.IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function.Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency.Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy.TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells.Plasmacytoid dendritic cells and the control of herpesvirus infections.Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathwaysCytoskeletal stabilization of inhibitory interactions in immunologic synapses of mature human dendritic cells with natural killer cells.Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner.Monocytes activate natural killer cells via inflammasome-induced interleukin 18 in response to hepatitis C virus replication.In Vivo Activation of Human NK Cells by Treatment with an Interleukin-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized MiceCutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo.Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice.Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.IL-15 receptor α signaling constrains the development of IL-17-producing γδ T cells.IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression.Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.Skeletal muscle interleukin 15 promotes CD8(+) T-cell function and autoimmune myositis.A targeted IL-15 fusion protein with potent anti-tumor activity.
P2860
Q26765345-30EF8B84-EB2D-4301-BD32-01061680E45DQ26825247-D9AC8E3F-383F-4877-98C4-E16661C0E28CQ27014714-7FEEEC89-6FEA-4946-8259-0FDFAC2CF9B3Q28085758-8027E7B5-D749-4BE7-96AD-07FB231B18D4Q28088784-99E5D23A-313D-4550-B3B6-BEFED8BD5B72Q28652428-10681304-3156-4B92-B753-73C83B5E4774Q33590390-B8C146A6-A80C-4A53-9C4E-6335D653B9E2Q33609436-AE9F0E60-B4D1-471C-A645-3D437671E7E1Q33656197-4E73E0CC-3883-4AD6-B268-73D466E1D2DCQ33767707-697E9ADE-FBE2-4EE3-B848-00DC830199EFQ33788829-67FF2CBB-0B32-4590-AACB-B28EAEFA4D92Q33849846-AEE8FAAB-1E30-4121-B3AE-2DD76435C425Q33965560-E104B6B7-7025-4D9F-9984-95FBB5B1CA51Q34017578-85D8A56A-DCF7-451D-8501-BD5CF9163771Q34076517-080CBDAD-FB04-43DD-957C-85B3F1D20623Q34314270-B2774382-94EA-4F81-BB16-AC5712064A97Q34328178-E47BD742-BC8D-4735-BB73-65B9E755E20FQ34354896-B57A8B10-8EC4-4A75-9E5D-B3DEB3D31179Q34548214-5EFDD260-ABCF-4A48-BBF5-475CA21D79FEQ34708192-E22F5BA4-F012-45B2-989B-893984CD56DAQ34924364-4C7ABF2F-82FB-4CE4-A224-9CA4311508DCQ34936507-3DFBFC3E-3D4E-43D0-BA26-4D3BA86A14F9Q35054508-180119DD-4385-451D-9D8B-6F74902E9EC3Q35204618-9884B388-5AFB-4560-97FD-DC94ECE44481Q35259804-507836CD-56F5-4702-8D8B-4700CF437D48Q35574404-8063D0C9-A4DA-41ED-8B27-F893C234436AQ35623632-156ED985-DA37-4ACC-B616-61FEB4CBA161Q35624376-A873C09C-07E2-49B6-BAC2-E68C9A31358CQ35748893-72E73B0A-EB9A-47C5-B7C6-D228EB9DE76EQ35760429-FA5C05D5-90DF-4E39-A863-1B12D17A87D9Q35803010-8066E29C-2070-4883-A56C-C6361A551420Q35842475-4E760448-3C86-4222-B961-A4791231503EQ35883106-4AEC86E8-BF4E-4730-B15A-28D1FFC95F1EQ35946210-89CCC9A5-EEDD-4CD7-8198-C84127F76E11Q35979037-A42BD0C9-DC78-457F-8C72-C9FBDF0CDCCCQ36014997-8544FDD8-7DE0-4DA4-83BD-8145052DA678Q36050117-8B409F9D-3988-4EB0-8FAE-E1B2D2796351Q36079820-30749E91-5246-4C8F-B8FF-AA3A642BC58BQ36096978-15D705A1-6F2D-4033-9E3C-652B86C7437DQ36214564-185F8FD6-1C13-422B-AEC4-EEA7FE35C21D
P2860
IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@ast
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@en
type
label
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@ast
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@en
prefLabel
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@ast
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@en
P2093
P2860
P356
P1476
IL-15Ralpha chaperones IL-15 t ...... cells via trans presentation.
@en
P2093
Erwan Mortier
Rommel Advincula
Sara Gozalo
P2860
P304
P356
10.1084/JEM.20071913
P407
P577
2008-05-05T00:00:00Z