Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
about
Outside-in signaling--a brief review of GPCR signaling with a focus on the Drosophila GPCR familyDisruption of G-protein γ5 subtype causes embryonic lethality in miceSmoothened goes molecular: new pieces in the hedgehog signaling puzzleSmoothened gene alterations in keratocystic odontogenic tumors.Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened SignalingDeterminant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons.Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse modelHeterotrimeric G protein signaling in polycystic kidney diseaseSmoothened is a poor prognosis factor and a potential therapeutic target in glioma.G-protein-coupled receptors, Hedgehog signaling and primary cilia.Canonical and non-canonical Hedgehog signalling and the control of metabolism.Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP LevelsRapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling.The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development.Autophagic Flux is Regulated by Interaction Between the C-terminal Domain of Patched1 and ATG101.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G13.Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
P2860
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P2860
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@ast
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@en
type
label
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@ast
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@en
prefLabel
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@ast
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@en
P2093
P2860
P356
P1476
Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
@en
P2093
Andrew E Douglas
David R Manning
Natalia A Riobo
P2860
P304
P356
10.1124/MOL.112.082511
P577
2013-01-04T00:00:00Z