about
Tiny Microbes with a Big Impact: The Role of Cyanobacteria and Their Metabolites in Shaping Our FutureConstraining cyclic peptides to mimic protein structure motifs.Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca spEvaluation of class I HDAC isoform selectivity of largazole analoguesModulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug PropertiesSynthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsSeaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathwayBiological targets and mechanisms of action of natural products from marine cyanobacteria.Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal CancerChemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria.Discovery and mechanism of natural products as modulators of histone acetylation.Largazole pharmacokinetics in rats by LC-MS/MS.Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens.Muscarine, imidaozle, oxazole and thiazole alkaloids.Natural products as zinc-dependent histone deacetylase inhibitors.Synthesis and biological evaluation of largazole zinc-binding group analogs.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation.Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.Mass spectrometry-based assay for the rapid detection of thiol-containing natural products.Quantitative measurement of intracellular HDAC1/2 drug occupancy using a -cyclooctene largazole thiol probe
P2860
Q26747668-C5B1D6F8-721E-4DD8-97BD-B07FDCEAB680Q30367509-3F042D62-28C1-4BBD-A73A-43C4A6142D57Q30684975-8D9FB36F-2571-4547-8AD0-B6AB6D46C51EQ34054267-9AF3C0D0-320D-4464-93C8-5DE6EE6D6420Q34063722-B64ADBA3-3A3F-4804-85D3-6AB94E18F4F3Q34302247-283DA4F5-44DA-4E35-B808-46F41F8BF60EQ34537322-74E7647E-572C-470C-9ED3-AF1DFCB31716Q35130835-F5147B94-3C25-439D-869F-61802DC5DA11Q35656966-C99BB147-954D-4924-8193-CED1A38C1A49Q35920661-DC7B48CD-BAB1-4D04-88E4-7D54152AE6D5Q35944520-415AC3CC-5F45-4E82-9376-45544B63D67BQ36994250-08327A00-79DD-4BFE-9D60-FCA277147990Q37242496-ADEC62DF-D908-4021-A6B6-FB23B8B3BD6CQ37667033-9937A105-038D-47F4-B66C-8CD92D9140E6Q37672660-715E545F-CD72-43C2-8040-C0076C6ED1D2Q38104230-66120606-0DDB-4D81-B0FF-1C91C65B9509Q38315538-0033D4E2-E680-4F7A-BCB6-A28222C0A264Q38707248-1D0B2B21-D196-4E46-859D-D3E4B0C1CF12Q38982458-C8459E57-7387-47E6-BD15-397796E88D7CQ39007306-7A731FE8-BFA6-4A5C-B3A9-DDF90531E552Q40091545-09BB6D37-F0DE-4230-A68E-7D6194FE34F8Q47154262-22956DFA-F823-41E6-BFA1-01D6A9A59FC5Q51755936-42F917B0-72DE-4199-BC42-EB906379BBD1Q52646693-49B068B7-6CBC-4563-82F7-F956A5BC9173Q52838941-BA985D67-236B-4432-B727-49B5684298DBQ58292982-4F07F735-6569-4ECA-8C7C-0651CB77F639
P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Largazole: from discovery to broad-spectrum therapy.
@ast
Largazole: from discovery to broad-spectrum therapy.
@en
type
label
Largazole: from discovery to broad-spectrum therapy.
@ast
Largazole: from discovery to broad-spectrum therapy.
@en
prefLabel
Largazole: from discovery to broad-spectrum therapy.
@ast
Largazole: from discovery to broad-spectrum therapy.
@en
P2860
P356
P1476
Largazole: from discovery to broad-spectrum therapy.
@en
P2093
Hendrik Luesch
Jiyong Hong
P2860
P304
P356
10.1039/C2NP00066K
P577
2012-02-14T00:00:00Z